发酵法制备富马酸的关键技术及其进展  

Key technologies and their advances for fumaric acid production by fermentation process

作　　者：李霜[1] 徐晴[1] 黄和[1] 

机构地区：[1]南京工业大学生物与制药工程学院,南京211800

出　　处：《生物加工过程》2013年第2期52-57,共6页Chinese Journal of Bioprocess Engineering

基　　金：国家高技术研究发展计划(863计划)重大项目(2011AA02A206);国家自然科学基金(21076104;21106065)

摘　　要：随着人们对食品领域安全的关注以及石油基富马酸价格的不断攀升,利用可再生生物质原料发酵法制备富马酸备受关注。探讨了发酵法制备富马酸的关键技术问题,从菌种改造、淀粉基原料发酵、纤维质原料发酵以及非钙盐中和等工艺角度阐述了富马酸工业化生产的技术和经济可行性。The growing concern of the safety of food additives and the increment cost of petroleum-based fumaric acid raised the interest of fermentation processes for fumaric acid production from renewable resources. The key problems for industrial production of fumaric acid were reviewed. Strategies for efficient microbial fumaric acid production, including strain improvement, process development and separation process were reviewed and discussed for the technological possibility and economic feasibility in industrial process.

关 键 词：富马酸 发酵 根霉菌 同步糖化发酵 反应分离耦合 

分 类 号：TQ921[轻工技术与工程—发酵工程]