番茄红素对大鼠急性心肌缺血的保护作用  

Protective Effect of Lycopene on Acute Myocardial Ischemia in Rats

作　　者：杨艳晖[1] 王海霞[1] 荣胜忠[2] 张广滕[3] 潘洪志[3] 

机构地区：[1]哈尔滨医科大学附属第二医学院,黑龙江哈尔滨150086 [2]牡丹江医学院公共卫生学院 [3]哈尔滨医科大学公共卫生学院

出　　处：《实用预防医学》2013年第4期476-478,共3页Practical Preventive Medicine

基　　金：黑龙江省卫生厅资助项目(2011-052)

摘　　要：目的探讨番茄红素对大鼠急性心肌缺血所致心肌损伤的保护作用。方法 60只雄性Wistar大鼠随机分为三组,分别为对照组、番茄红素高剂量组(10 mg/kg.bw)、番茄红素低剂量组(5 mg/kg.bw),对照组灌喂橄榄油,番茄红素组灌喂番茄红素。4周后,结扎大鼠心脏左冠状动脉前降支,建立大鼠急性心肌缺血模型,记录心电图,心脏切片计算心肌梗死面积。结果番茄红素可明显缩小梗死面积,番茄红素高剂量组几乎无心颤与心速,图形较好,6 h成活率100%,与对照组比较差异有统计学意义(P<0.05);低剂量图形次于高剂量,有少量的心速、早搏波,6 h成活率与对照组比较差异有统计学意义(P<0.05)。结论番茄红素对急性心肌缺血具有明显保护作用,对缺血诱发的心律失常亦有治疗作用,其机制可能与其增强抗氧化酶活性,减少自由基对心肌的氧化损伤,稳定生物膜有关。Objective To explore the protective effect of lycopene on myocardial injury in model rats with acute myocardial ischemia （AMI）. Methods Sixty male Wistar rats were randomly divided into 3 groups. The rats in the high dose and low dose groups were subjected to gavage administration of lycopene （10 mg/kg· bw and 5 mg/kg· bw, respectively）. The rats in the control group were subjected to oral gavage with olive oil. Four weeks later, all rats＇ left anterior descending coronary arteries were ligated to make into acute myocardial ischemia models. Electrocardiogram （ECG） was done and the infarct size was detected. Results Lycopene reduced the infarct area of myocardium at the doses of 5 mg/kg＂ bw and 10 mg/kg＂ bw. The 6 - hour survival rates of rats in the high- dose group which showed no atrial fibrillation and tachycardia and the low- dose group which had few atrial fibrillation and tachycardia were both 100 %. There were statistically significant differences between the above- mentioned groups and control group （P 〈 0.05 ）. Conclusions Lycopene can protect rats against AMI and arrhythmia induced by AMI, and its mechanism may be related to enhancing the activity of superoxide dismutase （SOD）, increasing malonaldehyde （MDA） content, improving free radical metabolism, and stabilizing myocardial cellular membrane.

关 键 词：急性心肌缺血 番茄红素 心电图 心肌梗死率 

分 类 号：R-332[医药卫生]