Research development of the relationship between thymidine phosphorylase expression and colorectal carcinoma  

作　　者：Dian-Jun Ye Ji-Min Zhang 

机构地区：[1]Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Guangzhou Medical University

出　　处：《Cancer Biology & Medicine》2013年第1期10-15,共6页癌症生物学与医学（英文版）

摘　　要：Thymidine phosphorylase (TP) is a key enzyme that contributes to the composition and decomposition of pyrimidine nucleotides. TP seems homologous to platelet-derived endothelial cell growth factor, and its effects on inducing vascularization and anti-apoptosis are closely related to growth and metastasis of colorectal carcinoma. In addition, TP is a key enzyme that catalyzes the transformation from 5-fluorouracil (FU) prodrugs of 5′-deoxy-5-fluorouridine (5′- DFUR) to 5-FU. The activity of TP is closely related to the sensitivity of colorectal carcinoma cells to fluorouracil drugs and targeted therapy. Given the important functions of TP in growth, metastasis, tumor treatment, and prognosis, determining its expression mechanism is significant. This article summarizes the research development of TP expression in colorectal carcinoma, tumor neovascularization, cytotoxicity activation of 5′-DFUR, and colorectal carcinoma therapy.Thymidine phosphorylase （TP） is a key enzyme that contributes to the composition and decomposition ofpyrimidine nucleotides. TP seems homologous to platelet-derived endothelial cell growth factor, and its effects on inducing vascularization and anti-apoptosis are closely related to growth and metastasis of colorectal carcinoma. In addition, TP is a key enzyme that catalyzes the transformation from 5-fluorouracil （FU） prodrugs of 5＇-deoxy-5-fluorouridine （5＇- DFUR） to 5-FU. The activity of TP is closely related to the sensitivity of colorectal carcinoma cells to fluorouracil drugs and targeted therapy. Given the important functions of TP in growth, metastasis, tumor treatment, and prognosis, determining its expression mechanism is significant. This article summarizes the research development of TP expression in colorectal carcinoma, tumor neovascularization, cytotoxicity activation of 5＇-DFUR, and colorectal carcinoma therapy.

关 键 词：1-hymidine phosphorylase colorectal carcinoma ANGIOGENESIS 5＇deoxy-5-fluorouridine 

分 类 号：R735.34[医药卫生—肿瘤]