人类白细胞抗原-DRB1等位基因多态性与中国人急性淋巴细胞白血病相关性的Meta分析  

Meta analysis in correlations between polymorphism of human leukocyte antigen-DRB1 alleles and acute lymphoblastic leukemia in Chinese population

作　　者：刘春艳[1,2] 柴晓静[2] 李娟[2] 韦丽娜[2] 赵丽[2] 

机构地区：[1]兰州大学第一临床医学院 [2]兰州大学第一医院中心实验室,甘肃兰州730000

出　　处：《临床荟萃》2013年第5期498-501,共4页Clinical Focus

摘　　要：目的系统评价研究人类白细胞抗原-DRB1(human leukocyte antigen,HLA-DRB1)等位基因与急性淋巴细胞白血病(ALL)发病相关性的病例对照研究。方法检索以下数据库:PubMed、EMBASE、Web of Science、中国生物医学文献数据库(CBM)、中文科技期刊全文数据库(VIP)、中国期刊全文数据库(CNKI)及万方数据库,并辅以文献追溯的方法,收集国内外发表的相关病例对照研究,检索时间均从建库至2012年11月。两位研究者按纳入排除标准筛选文献并评价纳入研究质量,应用RevMan5.1软件进行Meta分析。结果共纳入7个病例对照研究,包含ALL病例676例。Meta分析结果显示:HLA-DRB1*01、03～16与中国人群ALL的发生无显著联系,但亚组分析显示HLA-DRB1*03、HLA-DRB1*13和HLA-DRB1*14可能为中国儿童ALL的拮抗基因,OR分别为0.07(95%CI=0.01～0.56,P<0.05)、0.08(95%CI=0.01～0.65,P<0.05)、0.09(95%CI=0.01～0.77,P<0.05)。结论现有研究表明,HLA-DRB1*01、03～16与中国人群ALL的发生无显著联系,但某些等位基因可能与抑制儿童ALL的发生有关。但由于纳入研究质量中等、样本量较小,需要进行更多设计严谨的高质量研究来进一步证实。Objective To investigate the correlations between polymorphism of human leukocyte antigen（HLA- DRB1） alleles and acute lymphoblastic leukemia（ALL） in Chinese population with meta-analysis. Methods PubMed, EMBASE,Web of Science,CBM,VIP, CNKI and WanFang Database were searched from their establishment to Nov. 2012 for case-control studies investigating the relationship between polymorphism of HLA-DRB1 alleles and ALL in Chinese population. After evaluating methodological quality of studies that met the inclusion criteria, two researchers analyzed the data using Rev Man 5.1. Results Seven case-control studies were identified. Meta analysis.showed that,as for the expression of HLA-DRB1 ＊ 01,03-16, there were no significant differences between ALL and healthy people. But the subgroup analysis showed that HLA-DRB1 ＊ 03, HLA-DRB1 ＊ 13 and HLA-DRB1 ＊ 14 were the protection factors against ALL for children, the values of pooled odds ratio were 0.07 （95 % CI= 0. 01 0.56, P 〈0.05）, 0.08 （95% CI =0. 01-0. 65, P d0.05） and 0.09（95% CI =0.01-0.77, P d0.05）,respectively. Conclusion The current evidence shows that there is no relationship between polymorphism of HLA-DRB1 alleles and ALL in Chinese population,but some HLA-DRB1 alleles may be the protection factors against ALL for children,which need more high quality case-control studies to explore the question clearly.

关 键 词：白血病 淋巴细胞 急性 HLA—DR抗原 等位基因 META分析 病例对照研究 

分 类 号：R733.711[医药卫生—肿瘤]