Neamine-heterocycle conjugates as potential anti-HIV agents  

作　　者：Ri-Bai Yan Yan-Fen Wu Jun Liu Xiao-Lian Zhang Xin-Shan Ye 

机构地区：[1]State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences,Peking University [2]State Key Laboratory of Virology,Department of Immunology,Hubei Province Key Laboratory of Allergy and Immunology,Wuhan University School of Medicine

出　　处：《Chinese Chemical Letters》2013年第4期273-278,共6页中国化学快报（英文版）

基　　金：financially supported by the Ministry of Science and Technology of China(Nos.2012ZX09502001-001, 2012CB822100,and 2012CB720604);the National Natural Science Foundation of China(Nos.81025008 and 30921001)

摘　　要：A series of neamine-heterocycle conjugates were designed and synthesized. All new compounds displayed more potent inhibitory effect on HIV replication than neamine, among them two compounds displayed stronger anti-HIV activity than neomycin B. The results suggested that it might be a promising approach to modify neamine for the discovery of new anti-HIV agents.A series of neamine-heterocycle conjugates were designed and synthesized. All new compounds displayed more potent inhibitory effect on HIV replication than neamine, among them two compounds displayed stronger anti-HIV activity than neomycin B. The results suggested that it might be a promising approach to modify neamine for the discovery of new anti-HIV agents.

关 键 词：AMINOGLYCOSIDE ANTI-HIV Neamine SYNTHESIS 

分 类 号：TQ460.1[化学工程—制药化工]