Prognosis in prolonged coma patients with diffuse axonal injury assessed by somatosensory evoked potential  

作　　者：Xiujue Zheng Mantao Chen Jingqi Li Fei Cao 

机构地区：[1]Department of Neurosurgery,First Affiliated Hospital,School of Medicine,Zhejiang University [2]Hangzhou Hospital of Zhejiang Armed Police Corps

出　　处：《Neural Regeneration Research》2013年第10期948-954,共7页中国神经再生研究（英文版）

基　　金：funded by Zhejiang Medicines &Health Sciences Research Fund (Class A) in 2009, No.2009A086

摘　　要：A total of 43 prolonged coma patients with diffuse axonal injury received the somatosensory evoked potential examination one month after injury in the First Affiliated Hospital, School of Medicine, Zhejiang University in China. Somatosensory evoked potentials were graded as normal, abnormal or absent （grades I-III） according to N20 amplitude and central conduction time. The outcome in patients with grade III somatosensory evoked potential was in each case unfavorable. The prognostic accuracy of grade III somatosensory evoked potential for unfavorable and non-awakening outcome was 100% and 80%, respectively. The prognostic accuracy of grade I somatosensory evoked potential for favorable and wakening outcome was 86% and 100%, respectively. These results suggest that somatosensory evoked potential grade is closely correlated with coma severity and degree of recovery. Somatosensory evoked potential is a valuable diagnostic tool to assess prognosis in prolonged coma patients with diffuse axonal injury.A total of 43 prolonged coma patients with diffuse axonal injury received the somatosensory evoked potential examination one month after injury in the First Affiliated Hospital, School of Medicine, Zhejiang University in China. Somatosensory evoked potentials were graded as normal, abnormal or absent （grades I-III） according to N20 amplitude and central conduction time. The outcome in patients with grade III somatosensory evoked potential was in each case unfavorable. The prognostic accuracy of grade III somatosensory evoked potential for unfavorable and non-awakening outcome was 100% and 80%, respectively. The prognostic accuracy of grade I somatosensory evoked potential for favorable and wakening outcome was 86% and 100%, respectively. These results suggest that somatosensory evoked potential grade is closely correlated with coma severity and degree of recovery. Somatosensory evoked potential is a valuable diagnostic tool to assess prognosis in prolonged coma patients with diffuse axonal injury.

关 键 词：neural regeneration brain injury somatosensory evoked potential diffuse axonal injury COMA PROGNOSIS AWAKENING nerve electrophysiology grants-supported paper NEUROREGENERATION 

分 类 号：R741[医药卫生—神经病学与精神病学]