酒精性肝病患者血清NO、TNF-α和IL-6的检测及意义  

Detection of serum NO、TNF-α and IL-6 in patients with alcoholic liver disease and their significances

作　　者：王欣[1] 张明威[2] 孙淑艳[1] 

机构地区：[1]白求恩医科大学第一临床学院,吉林长春130021 [2]白求恩医科大学第二临床学院,吉林长春130041

出　　处：《临床肝胆病杂志》2000年第3期163-164,共2页Journal of Clinical Hepatology

摘　　要：本文应用比色法和酶联免疫吸附法检测了48例酒精性肝病三个不同时期(酒精性脂肪肝、酒精性肝炎和酒精性肝硬化)患者血清中NO、ＴＮＦ－α、ＩＬ－６的浓度。结果显示：酒精性脂肪肝和酒精性肝炎患者血清ＴＮＦ－α、ＩＬ－６浓度均高于正常对照组（Ｐ＜０．０１）。提示：NO、ＴＮＦ－α及ＩＬ－６在酒精性肝病从酒精性脂肪肝酒精性肝炎酒精性肝硬化的发展过程中起一定的作用，联合检测对判断酒精性肝病病程及预后有一定的指导意义。Serum NO and serum TNF-α,IL-6 were measured by colorimetric and ELISA method in 48 patients with alcoholic liver disease(ALD) including 18 alcoholic fatty liver(AF) patients,2 1alcoholic hepatitis(AH)patients and 9 alcoholic cirrhosis(AC) pantients.The results showed that the serum TNF-α,IL-6 in AF and AH patients were significantly higher than that in normal controls( P<0.01) The serum NO,TNF-α,IL-6 in AC patients were significantly higher than that in normal controls(P<0.01).we can concluded that increased serum NO,TNF-α and IL-6 have important roles in the development of ALD from AF to AH and AC

关 键 词：一氧化氮 酒精性肝病 TNFΑ 白细胞介素6 诊断 

分 类 号：R575[医药卫生—消化系统]