微生物发酵法生产纤溶酶的研究进展  

Advances in fibrinolytic enzyme preparation by microbial fermentation

作　　者：艾瑞波[1] 刘晓兰[1,2] 邓永平[1,2] 李琰[1,2] 何宁[1] 王晓杰[1,2] 袁欣[3] 

机构地区：[1]齐齐哈尔大学食品与生物工程学院,黑龙江齐齐哈尔161006 [2]黑龙江省普通高等学校农产品加工重点实验室,黑龙江齐齐哈尔161006 [3]齐齐哈尔市环境监测中心站,黑龙江齐齐哈尔161006

出　　处：《食品与机械》2013年第2期227-230,共4页Food and Machinery

基　　金：黑龙江省教育厅科学技术研究项目(编号:12521598);国家自然科学基金资助项目(编号:31171744)

摘　　要：血栓类疾病严重威胁人类生命和健康,溶栓疗法是目前治疗该类疾病安全有效的手段,传统的溶栓药物疗效显著,但是还存在一定缺陷。目前,利用微生物发酵产生的纤溶酶制备溶栓药物已经成为研究热点。文章对不同微生物来源的纤溶酶的发酵、分离纯化及性质等方面的资料进行总结,并对纤溶酶研发领域存在的问题进行探讨。Thrombotic diseases are serious threat to human life and health. Thrombolytic therapy used for the treatment of such diseases is safe and effective means of thrombolytic drug efficacy significantly. However, there are still some defects in the present therapy. At present, preparation of fibrinolytic enzymes produced by microbial fermentation as thrombolytic drugs has become a hot research topic. In the present paper, ferementation, purification, and biochemical characteristics of fibrinolytic enzymes from different microbial sources are summarized, and the problems in this field of research are discussed.

关 键 词：微生物 发酵 纤溶酶 纯化 性质 

分 类 号：TQ925[轻工技术与工程—发酵工程]