免疫毒素用于自体骨髓移植治疗白血病的实验研究及初步临床  

Autologous Bone Marrow Transplantation with Marrow Decontaminated by Immunotoxins in the Treatment of Leukemia

作　　者：沈倍奋[1] 黎燕[1] 贺永怀[1] 陈兴[1] 汲言山[1] 赵薇薇[1] 王文香[1] 杨科[2] 藤爱萍 梅巍[2] 

机构地区：[1]军事医学科学院基础医学研究所,北京100850 [2]北京军区总医院血液科

出　　处：《单克隆抗体通讯》1991年第4期6-10,共5页

摘　　要：目前自体骨髓移植被越来越多地用于白血病治疗,然而在缓解期从病人抽取的骨髓细胞可能含有残留的肿瘤细胞,当大剂量放、化疗后回输给病人,将来有可能引起白血病复发。现在有很多方法可以用来去除这些瘤细胞,免疫毒素是安全有效的方法之一。本文报道了由抗CD2、CD5和CD8单抗与蓖麻毒素组成的抗T免疫毒素,抗CD9、CD10单抗与蓖麻毒素组成的抗C-ALL免疫毒素在体外对靶细胞的特异性细胞毒作用,及用于临床净化骨髓的初步结果。Autologous bone marrow transplantation is currently used by many groups for treating acute leukemia. However, the bone marrow of patients with leukemia collected during complete remission may contain residual tumor cells. When infused back into the patient following supralethal chemo-radiotherapy, they might cause relapse of the disease.Though various methods have been tried to remove such cells, immunotoxin is one of the safest and most effective methods. Two kinds of immunotoxins have been prepared. Anti-T immunotoxin consists of anti-CD2, CD5 and CD8 monoclonal antibodies and ricin. Anti-C-ALL immunotoxin is composed of anti-CD9,CD10 monoclonal antibodies and ricin. Specific cytotoxicity of both the immunotoxins to the target cells in vitro and preliminary application of the bone marrow ex vivo have been asscessed in clinical practice.

关 键 词：自体骨髓移植 免疫毒素 白血病 

分 类 号：R733.705[医药卫生—肿瘤]