血液学检查在产前地贫筛查中的作用  

Analysis on effect of hematological exernlrmtion in prenatal thalassemia screening

作　　者：苏巧云[1] 杨凤啸[1] 唐希才[1] 

机构地区：[1]广州医学院第三附属医院,广州510150

出　　处：《国际医药卫生导报》2013年第10期1427-1429,共3页International Medicine and Health Guidance News

摘　　要：目的0探讨常规血液学检查在孕妇进行地中海贫血（地贫）产前筛查中的作用。方法选择2011年10月至2012年9月在我院接受产前筛查的2443例孕妇作为研究对象。血常规、血清铁和血红蛋白电泳检查作为孕妇的常规产检项目，孕妇的配偶同时作血常规检查，对筛查阳性病例做基因诊断检查。结果血红蛋白电泳检测发现HbA，异常孕妇629例，进一步对其进行基因检测，发现夫妻同表型者59例，夫妻同基因型54例，共确诊地贫胎儿52例（0L一地贫24例、B一地贫28例），其中重型地贫胎儿5例（0L一地贫2例，B一地贫3例）。629例HbA：异常的孕妇红细胞计数（RBC）、血红蛋白（Hb）、红细胞平均体积（MCV）均明显低于正常水平（P〈0．05），红细胞分布宽度（RDW）明显高于正常水平（P〈0．05）。结论血常规红细胞参数和血红蛋白电泳等血液学检查在地贫产前筛查中有一定的作用。Objective Tinvesgatemethdsresutsandeecveofhematgicaexaminatininprenaa thaasscm screening in pregnant women. Methods We selected 2443 cases of prenatal screening pregnant women from September 2011 to December 2012 in our hospital as the research object. At present we had blood routine, serum iron and hemoglobin electrophoresis check to pregnant women as conventional production test project, gave pregnant women spouse the blood routine inspection, the screening positive cases were accepted with gene diagnosis inspection. Hemoglobin eleclrophoresis test found 629 cases of HbA2 abnomud, further genetic tests results found that couples with same phenotypic 59 cases, couples with same genotype 54 ones, confimed 52 thalassemia fetus （α -thalassemia 24 cases, β-thalassemia 28 eases）. 5 cases of severe thalassemia fetus （ α -tha]assemia 2 cases, β-thalassemia 3 eases）. The RBC, Hb and MCV were all lower than normal levels （P 〈 0.05）. The RBC volume distribution width （RDW） was obviously higher than the laormal level （P 〈 0.05）. Conclusion Hematological examination such as blood routine RBC parameters and hemoglobin electrophoresis has certain effect in prenatal thalassemia screening.

关 键 词：孕妇 地中海贫血 产前诊断 血液学检查 

分 类 号：R446.1[医药卫生—诊断学] R714.5[医药卫生—临床医学]