侵袭性垂体腺瘤中Fascin蛋白、MMP-2和MMP-9的表达与研究  

Expressions of Fascin,MMP-2 and MMP-9 in Invasive Pituitary Adenomas

作　　者：谢民[1] 丁永忠[1] 周旺宁[1] 段磊[1] 梁强[1] 杨鹏宇[1] 

机构地区：[1]兰州大学第二医院神经外科,甘肃兰州730030

出　　处：《中国神经肿瘤杂志》2013年第1期15-21,共7页Chinese Journal of Neuro-Oncology

摘　　要：目的:垂体腺瘤侵袭性生长的机制还不清楚。本研究旨在检测肌动蛋白结合蛋白(Fascin)及基质金属蛋白酶-2(matrix metalloproteinases MMP-2)和基质金属蛋白酶-9(matrix metalloproteinases MMP-9)在侵袭性垂体腺瘤中的表达水平,分析其与垂体腺瘤的生长侵袭性之间的可能关系。方法:免疫组织化学SP法检测三者在72例垂体腺瘤(侵袭性27例,非侵袭性45例)中的表达水平,统计学分析三者在垂体腺瘤中表达差异性,及与不同临床特征的表达相关性。结果:Fascin蛋白、MMP-2及MMP-9在侵袭性垂体腺瘤的表达水平高于非侵袭性垂体腺瘤(t=3.03,t=3.33,t=2.02,P<0.05)。三者在垂体腺瘤中表达水平与患者性别无明显相关,与肿瘤有无分泌功能无明显相关,但与肿瘤大小有关(χ2值分别为8.53,11.31,12.46,P<0.05)。结论:Fascin蛋白、MMP-2及MMP-9在侵袭性垂体腺瘤中高表达,提示三者可能与垂体腺瘤侵袭性生长密切相关。BACKGROUND ＆ OBJECTIVE： The mechanism underlying the invasion of pituitary adeno- mas is still unclear. The aim of this study was to determine the potential relationship between the invasiveness of adeno- mas and expressions of 3 proteins, aetin-binding protein （Fascin） and matrix metalloproteinases （MMP-2 and MMP-9）. METHODS： Immunohistochemistry assay was used to detect expressions of 3 proteins in 72 patients with pituitary ade- nomas （27 invasive adenomas and 45 non-invasive adenomas）. The differences of expressions of 3 proteins were statisti- cally analyzed. RESULTS： Expressions of Fascin, MMP-2 and MMP-9 in invasive group were higher than the non-inva- sive group （t=3.03, t=3.33, t=2.02, P〈 0.05）. Gender of patients and the function of endocrine did not have relationship with expressions of 3 proteins. But size of tumor did （X2 = 8.53, 11.31, 12.46, P〈 0.05）. CONCLUSION： Our study suggest that high expressions of Fasein, MMP-2 and MMP-9 may be indexes to the invasiveness of pituitary adenomas.

关 键 词：垂体腺瘤 FASCIN MMP-2 MMP-9 侵袭性 

分 类 号：R739.41[医药卫生—肿瘤]