叶黄素治疗年龄相关性黄斑变性的临床研究  

Clinical Trial of Lutein on Treatment of Age-related Macular Degeneration

作　　者：夏立营[1] 刘维佳[1] 寇秋爱[1] 周佩云[1] 李跃虹[2] 李明喜[1] 崔坤敏[1] 葛文津[1] 

机构地区：[1]中国中医科学院西苑医院中医药保健研究中心,北京100091 [2]中国中医科学院西苑医院眼科,北京100091

出　　处：《世界中医药》2013年第5期517-519,共3页World Chinese Medicine

摘　　要：目的:观察叶黄素治疗年龄相关性黄斑变性的临床疗效。方法:采用随机、对照、双盲方法,观察83例患者服食叶黄素咀嚼片前后137只眼睛视力、眼底黄斑变化。结果:治疗组显效11眼,有效31眼,无效32眼,总有效率56.76%;对照组显效0眼,有效19眼,无效44眼,总有效率30.16%。2组比较有统计学意义(P<0.001)。结论:叶黄素对年龄相关性黄斑变性患者眼底表现及视力有一定改善作用。Objective： To evaluate the clinical therapeutic effect of Lutein on the treatment of age-related macular degeneration （AMD）. Methods： 137 eyes of 83 AMD patients were randomized in a controlled, double blind trial. The treatment group was treated with lutein chewable tablets and the control group were treated with placebo. After 3-month treatment, the changes of distant vision and puncta luteum in OCT were observed. Results：The total effective rate of the treatment group was 56.76%, significant better than 30.16% of the control group （P 〈 0. 001 ）. Conclusion： Lutein showed therapeutic effect for age-related macular degeneration, such as improving visual activity, elimination of retina edema and atrophying.

关 键 词：临床研究 年龄相关性黄斑变性 叶黄素 

分 类 号：R774.5[医药卫生—眼科]