Progesterone treatment before experimental hypoxia-ischemia enhances the expression of glucose transporter proteins GLUT1 and GLUT3 in neonatal rats  

作　　者：Xinjuan Li Hua Han Ruanling Hou Linyu Wei Guohong Wang Chaokun Li Dongliang Li 

机构地区：[1]Department of Physiology and Neurobiology, Xinxiang Medical University [2]Department of Ultrasonic Diagnosis, Central Hospital of Xinxiang City [3]Henan Key Lab of Biological Psychiatry

出　　处：《Neuroscience Bulletin》2013年第3期287-294,共8页神经科学通报（英文版）

基　　金：supported by the National Natural Science Foundation of China (81100912);the Science Foundation of Xinxiang Medical University, China (CL and ZD 2009-63);the Science and Technology Project of Henan Province, China (092102310098)

摘　　要：Progesterone is an efficient candidate for treating stroke and traumatic brain damage. The current study was designed to investigate the effects of pro gesterone on glucose transporter proteins （GLUT1 and GLUT3） during hypoxicischemic injury in a neo natal rat model. We demonstrated strong staining for GLUT1 in the walls of blood vessels and GLUT3 im munoreactivity in hippocampal neurons after hypoxia ischemia. Hypoxiaischemia elevated GLUT1 and GLUT3 at both the mRNA and protein levels in the hippocampus, and pretreatment with progesterone （8 mg/kg） further enhanced their accumulation until 24 h after hypoxicischemic injury. These results showed that progesterone treatment induced the accumula tion of both GLUT1 and GLUT3 transporters, and an energycompensation mechanism may be involved in the neuroprotective effect of progesterone during hy poxicischemic injury after cerebral ischemic attacks.Progesterone is an efficient candidate for treating stroke and traumatic brain damage. The current study was designed to investigate the effects of pro gesterone on glucose transporter proteins （GLUT1 and GLUT3） during hypoxicischemic injury in a neo natal rat model. We demonstrated strong staining for GLUT1 in the walls of blood vessels and GLUT3 im munoreactivity in hippocampal neurons after hypoxia ischemia. Hypoxiaischemia elevated GLUT1 and GLUT3 at both the mRNA and protein levels in the hippocampus, and pretreatment with progesterone （8 mg/kg） further enhanced their accumulation until 24 h after hypoxicischemic injury. These results showed that progesterone treatment induced the accumula tion of both GLUT1 and GLUT3 transporters, and an energycompensation mechanism may be involved in the neuroprotective effect of progesterone during hy poxicischemic injury after cerebral ischemic attacks.

关 键 词：hypoxic-ischemic injury PROGESTERONE GLUT1 GLUT3 stroke 

分 类 号：R96[医药卫生—药理学]