腺苷钴胺治疗急性视神经炎的临床观察  

Clinical observation of cobamamide in the treatment for acute optic neuritis

作　　者：盖春柳[1] 底煜[1] 徐晓鹤[1] 

机构地区：[1]中国医科大学附属盛京医院眼科,沈阳110004

出　　处：《实用药物与临床》2013年第5期418-419,共2页Practical Pharmacy and Clinical Remedies

摘　　要：目的观察肌注腺苷钴胺治疗急性视神经炎的临床疗效。方法将41例(57眼)患者随机分为2组:腺苷钴胺治疗组22例(31眼),肌肉注射1.5 mg,1次/d;Vit B12治疗组19例(26眼),肌肉注射0.5 mg,1次/d,15 d为1个疗程,两组同时联合应用大剂量糖皮质激素。对比两组治疗前后视力、VEP的改善情况和疗效。结果两组总有效率差异无统计学意义(P>0.05),显效率差异有统计学意义(P<0.05)。结论急性视神经炎早期大剂量激素联合腺苷钴胺肌注综合治疗作用明显,临床效果优于Vit B12,对视功能的恢复作用较好。Objective To observe the clinical effect of cobamamide in the treatment for acute optic neuritis. Methods 41 patients（57 eyes）with acute optic neuritis were randomly divided into two groups：cobamamide group （22 cases,31 eyes）and Vit BI2 group（ 19 cases,26 eyes）. Patients of the two groups were treated with cobamamide （ 1.5 mg, once daily）or Vit B I2 （0. 5 mg, once daily）respectively, and high-dose ghicocorticoid hormone was used sim- ultaneously,the course was 15 d. Visual acuity, effect and the improvement of VEP were compared between the two groups before and after treatment. Results There was no significant difference in total effective rate between the two groups（ P 〉 0. 05 ）. The significant efficiency rate of cobamamide group was higher than that of Vit B12 group（ P 〈 0. 05 ）. Conclusion The treatment for acute optic neuritis with early high-dose hormone combined with cobarnamide is effective obviously ,the recovery of visual function and clinical effect is better than Vit B12.

关 键 词：急性视神经炎 腺苷钴胺 VIT B12 

分 类 号：R774.6[医药卫生—眼科]