盐酸替罗非班的合成研究  

Synthesis of Tirofiban Hydrochloride

作　　者：刘超[1] 陆旭芳[1] 耿元硕[1] 李志裕[1] 

机构地区：[1]中国药科大学药物化学教研室,江苏南京210009

出　　处：《精细化工中间体》2013年第2期42-45,65,共5页Fine Chemical Intermediates

摘　　要：以4-(4-哌啶基)-1-氯丁烷、L-酪氨酸等为原料经过7步反应得到盐酸替罗非班。此合成路线操作简易,总收率达21.6%,中间体及最终产物结构均经过MS和1H NMR确证。Tirofiban hydrochloride is a reversible non-peptide platelet GP IIb/IIIa receptor antagonist,for the treatment of acute coronary syndrome. This paper reported the synthesis of Tirofiban hydrochloride from 4-（4- piperidinyl）-1-chlorobutane and L-tyrosine via 7 steps of chemical reactions. This new synthesis route with low- toxicity and simple operation has a high yield which is up to 21.6%. The structures of the intermediates and the final product were certified by MS and 1H NMR.

关 键 词：血小板GPIIb IIIA受体拮抗剂 盐酸替罗非班 合成 

分 类 号：R737.902[医药卫生—肿瘤]