儿童急性白血病遗传学研究进展  

Progress of Studies on Genetics of Childhood Acute Leukemia——Review

作　　者：岳志霞[1] 郑胡镛[1] 

机构地区：[1]首都医科大学附属北京儿童医院血液肿瘤中心,北京市重点实验室,儿科学国家重点学科,北京100045

出　　处：《中国实验血液学杂志》2013年第3期791-795,共5页Journal of Experimental Hematology

基　　金：儿童白血病的国际化新药临床评价研究技术平台建设(编号2011ZX09302-007-01)

摘　　要：白血病特异染色体异常的确定及其与预后关系的研究对儿童急性白血病(acute leukemia,AL)具有极其重要的意义。近年来,虽然儿童AL的治疗效果有了很大改善,但其复发仍然是影响预后的主要因素。根据遗传学异常进行危险度分层,并指导治疗,可以改善儿童AL预后,提高患儿生存率。在过去的30年中,遗传学检测技术有了突飞猛进的发展,发现了许多新的遗传学异常。本文就三种儿童常见AL,包括前B细胞急性淋巴细胞白血病(B-cell precursor acute lymphoblastic leukemia,BCP-ALL)、T细胞急性淋巴细胞白血病(T-cell acute lymphoblasticleukemia,T-ALL)和急性髓系白血病(acute myeloid leukemia,AML)的最新遗传学研究进展进行综述。This study on determination of leukemia-specific chromosomal abnormalities and their relationship with prognosis of childhood acute leukemia（AL） had an important significance for childhood acute leukemia. In recent years, the efficacy of treatment of childhood AL has been greatly improved, but relapse is still a main factor affecting prognosis. Treatment based on the risk stratification by cytogenetic abnormalities can improve the prognosis and survival rate. In the past 3 decades, the genetic techniques have developed rapidly and many new genetic abnormalities have been found. This review highlights the main chromosomal and genomic abnormalities of 3 common childhood AL, including B-cell precursor acute lymphoblastic leukemia（ BCP-ALL）, T-cell acute lymphoblastic leukemia（T-ALL） and acute myeloid leukemia（AML）.

关 键 词：急性白血病 细胞遗传学 基因组学 染色体异常 

分 类 号：R733.71[医药卫生—肿瘤]