事件相关电位P300对农村轻度认知功能障碍患者认知功能的评价效果  

Evaluation of cognitive functions by audiory event related potential P300 in rural patients with mild cognitive impairments

作　　者：何冰[1] 卢国华[1] 杨增云[1] 范静波[1] 张媛媛[1] 张兰娥[1] 陈晓依[1] 

机构地区：[1]潍坊医学院护理学院,山东省潍坊市261053

出　　处：《国际神经病学神经外科学杂志》2013年第2期105-107,共3页Journal of International Neurology and Neurosurgery

基　　金：山东省自然科学基金(ZR2010HM042;ZR2011HM002)

摘　　要：目的分析农村轻度认知功能障碍(MCI)患者P300改变的特点,为提高农村轻度认知功能障碍的早期诊断水平提供方法。方法 2010年12月至2012年5月从潍坊市多个农村地区筛选MCI患者35例和无明显认知功能障碍的健康老人32例为研究对象,应用简易精神状态量表(MMSE)测评受试者认知功能状态,同时应用美国Neuroscan公司生产的ESI-64导脑电信号采集记录仪采用被动听觉oddball范式记录两组事件相关电位P300的情况评估受试者认知功能状况。结果两组MMSE测验总分在控制性别、年龄、教育水平等影响因素后差异有统计学意义(P<0.01)。MCI组P300潜伏期为比对照组(338.03±43.03)明显延长(P<0.01);波幅下降,但与对照组相比差异无统计学意义(P>0.05)。结论听觉事件相关电位P300潜伏期测定不受语言、文字限制,尤其适合对农村老年人的认知功能进行定量评价。在无损害的诊断与评定农村老年人轻度认知功能障碍方面有重要价值。Objective To analyze the characteristics of P300 event-related potential （ERP） in rural patients with mild cognitive impairment （MCI） and to provide a method for improved early diagnosis of MCI among rural residents. Methods Thirty-five MCI pa- tients （MCI group） and 32 healthy elderly residents without marked cognitive impairment （control group） were selected from the rural areas in Weifang City, China from December 2010 to May 2012. To evaluate the cognitive function of these subjects, mini-mental state examination （MMSE） was used, and the P300 ERPs of both groups were recorded with a passive auditory oddball paradigm using the ESI-64 system （Neuroscan Inc. , USA） that is used for collecting and recording EEG signals. Results After adjustment for such factors as sex, age, and educational level, the MMSE score showed a significant difference between the two groups （P 〈 0.01 ）. Compared with the control group, the MCI group had a significantly prolonged P300 latency （P 〈 0.01 ） and a reduced, but not statistically significant, P300 amplitude （P 〉 0.05）. Conclusions Measurement of auditory P300 ERP latency, not limited by language or text, is particularly suitable for quantitative evaluation of the cognitive function among the elderly in rural areas. It holds promise for noninvasive diagnosis and evaluation of MCI among the elderly in rural areas.

关 键 词：农村 轻度认知功能障碍 事件相关电位P300 简易精神状态量表 

分 类 号：R749.1[医药卫生—神经病学与精神病学]