低聚乳果糖粗品对断奶大鼠生长性能及血清生化指标的影响  

Effect of impure lactosucrose on growth performance andserum biochemical parameters in the weaning-rats

作　　者：黄小流[1,2] 肖凤[1] 王剑[1] 黄涛[1] 阮征[2,3] 

机构地区：[1]井冈山大学医学院,江西吉安343009 [2]南昌大学食品科学与技术国家重点实验室,江西南昌330047 [3]南昌大学生命科学与食品工程学院,江西南昌330031

出　　处：《食品工业科技》2013年第13期321-324,329,共5页Science and Technology of Food Industry

基　　金：国家自然科学基金项目(31001014);黎介寿院士肠道屏障研究专项基金项目(LJS_201006)

摘　　要：目的:探讨低聚乳果糖粗品(impure lactosucrose,ILS)在一周内对断奶大鼠生长性能和血清生化指标的影响。方法:选取24只断奶SD大鼠,分为3个组:对照组,低聚乳果糖粗品高剂量组,低聚乳果糖粗品低剂量组,各组基础日粮相同,实验为期一周,检测各指标。结果:与对照组相比,添加100mg/kg·BW低聚乳果糖粗品能显著降低断奶大鼠的体重(p<0.05)、平均日增重(p<0.05)、日均采食量(p<0.05)、肾脏相对指标(p<0.05)、血清中肌酸激酶水平(p<0.05);添加200mg/kg·BW低聚乳果糖粗品能显著降低断奶大鼠的日均采食量(p<0.05)、血清中肌酸激酶水平(p<0.05)、胆固醇含量(p<0.05)和尿素氮含量(p<0.05),显著增加结肠黏膜粘液层厚度(p<0.05)。结论:低聚乳果糖粗品在一周内能改善断奶大鼠机体脂质代谢、维持结肠黏膜完整性、缓解应激反应,对生长性能有负调控作用。Objective. Study on the effects of impure lactosucrose （ILS）on growth performance and serum biochemical parameters in weaning-rats in a week.Method.24 weaning rats were randomly assigned to 3 groups as follows：normal control, ILS high dose group and ILS low dose group, the same basal diet for each group, a week for the experiment, checked each target. Result. The body weight, AGD, ADFI, kidney relative indicator and creatine kinase levels in serum administrated with 100mg/kg.BW ILS were significantly reduced compared to rats in normal control group（p 〈 0.05）.The ADFI, creatine kinase levels in serum, concentration of the cholesterol and urea nitrogen in serum were significantly reduced （p 〈 0.05）, and the thickness of the colonic mucus layer was significantly increased （ p 〈 0.05） in weaning- rats treated with 200mg/kg ~ BW ILS compared to rats in normal control groupConclusion.lLS ameliorated lipid metabolism in organism,maintained the integrity of colonic mucous, relieved stress response,and had negative regulation of growth performance in weaning rats in a week.

关 键 词：低聚乳果糖粗品 断奶大鼠 生长性能 血清生化指标 

分 类 号：TS236[轻工技术与工程—粮食、油脂及植物蛋白工程]