PTEN基因在胃癌组织中的表达及其对患者预后的影响  

Expressions of PTEN as prognostic biomarker on resectable gastric cancer patients

作　　者：李爱萍[1] 夏晓伟[1] 陈颜夙[1] 张建兵[2] 周建伟[1] 

机构地区：[1]江苏南京市南京医科大学公共卫生学院,南京211166 [2]江苏省南通市南通市肿瘤医院病理科,南京南通226361

出　　处：《中国肿瘤临床与康复》2013年第6期562-565,共4页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的探讨胃癌组织和癌旁组织中PTEN基因的表达及其对患者预后的影响。方法收集1991年1月至1996年12月间收治的113例胃癌单纯手术治疗患者的临床病理资料和术后生存随访资料,将癌组织与相对应癌旁组织制作组织芯片,通过免疫组化的方法,分别获得PTEN基因在其中的表达评分。分析PTEN基因表达与患者临床病理指标及预后之间的关系。结果 113例患者中,最终获得108例患者的有效信息,PTEN基因在108例胃癌患者癌组织中的表达水平明显低于癌旁组织(P<0.001)。PTEN基因变化与患者年龄、组织浸润肿瘤侵袭深度、淋巴结转移率、远处转移率和TNM分期等方面差异无统计学意义(P>0.05),但是不同性别患者的PTEN基因表达差异明显,男性患者PTEN基因的低表达比例明显高于女性患者,(P=0.015)。胃癌组织中PTEN基因表达水平明显低于癌旁组织,胃癌组织中PTEN表达高的患者其预后生存时间明显长于表达低的患者(P=0.0145)。结论 PTEN基因可作为预测手术治疗患者预后的主要生物标志物之一。Objective To investigate the PTEN expressions in gastric cancer tissue and the potential association with clinicopathological characteristics and prognosis of the patients.Methods The clinicopathological and survival information of the 108 cases was collected to establish a combined database.The tissue micro-array was made from the paraffin embed gastric cancer tissues and corresponding adjacent nontumoral gastric tissues from 109 resectable patients.Expressions of PTEN were evaluated by a semi-quantitative immunoreactivity scoring（IRS） procedure.The correlations between the expressions of the PTEN and clinicopathological as well as survival characteristics of patients were further analyzed.Results Expressions of PTEN were significantly lower in cancer lesions than in adjacent noncancerous tissues.Low tumoral PTEN expression in cancerous tissues were significantly correlated with shorter overall survival（OS）in patients（P0.001）.Conclusions PTEN might be a novel biomarker for earlier progression and prognosis of resectable gastric cancer patients.

关 键 词：PTEN基因 胃肿瘤 预后 标志物 

分 类 号：R735.2[医药卫生—肿瘤]