X-irradiation for inhibiting glial scar formation in injured spinal cord  

作　　者：Guangzhi Ning Renhui Chen Yulin Li Qiang Wu Qiuli Wu Yan Li Shiqing Feng 

机构地区：[1]Department of Orthopedics, Tanjin Medical University General Hospital [2]Department of Orthopedics, Tianjin 4th Central Hospital

出　　处：《Neural Regeneration Research》2013年第17期1582-1589,共8页中国神经再生研究（英文版）

基　　金：supported by the National Natural Science Foundation of China, No. 81070982, 81201400;Tianjin Research Program of Application Foundation and Advanced Technology, No. 10JCZDJC18800, 13JCQNJC11100;the Research Foundation of Tianjin Health Bureau, No. 09kz104

摘　　要：X-irradiation has a beneficial effect in treating spinal cord injury. We supposed that X-irradiation could improve the microenvironment at the site of a spinal cord injury and inhibit glial scar formation. Thus, this study was designed to observe the effects of 8 Gy X-irradiation on the injury site at 6 hours and 2, 4, 7, and 14 days post injury, in terms of improvement in the microenvironment and hind limb motor function. Immunohistochemistry showed that the expression of macrophage marker ED-1 and the area with glial scar formation were reduced. In addition, the Basso, Beattie and Bresnahan score was higher at 7 days post injury relative to the other time points post injury. Results indicated that X-irradiation at a dose of 8 Gy can inhibit glial scar formation and alleviate the inflammatory reaction, thereby repairing spinal cord injury. X-irradiation at 7 days post spinal cord injury may be the best time window.X-irradiation has a beneficial effect in treating spinal cord injury. We supposed that X-irradiation could improve the microenvironment at the site of a spinal cord injury and inhibit glial scar formation. Thus, this study was designed to observe the effects of 8 Gy X-irradiation on the injury site at 6 hours and 2, 4, 7, and 14 days post injury, in terms of improvement in the microenvironment and hind limb motor function. Immunohistochemistry showed that the expression of macrophage marker ED-1 and the area with glial scar formation were reduced. In addition, the Basso, Beattie and Bresnahan score was higher at 7 days post injury relative to the other time points post injury. Results indicated that X-irradiation at a dose of 8 Gy can inhibit glial scar formation and alleviate the inflammatory reaction, thereby repairing spinal cord injury. X-irradiation at 7 days post spinal cord injury may be the best time window.

关 键 词：neural regeneration spinal cord glial scar X-IRRADIATION functional recovery ASTROCYTES grants-supported paper NEUROREGENERATION 

分 类 号：R651.2[医药卫生—外科学]