HLA-DRB1位点等位基因多态性与新疆汉族鼻咽癌的相关性研究  

A study on the correlation of HLA-DRBI and nasopharyngeal carcinoma among Han People in Xinjiang

作　　者：陈婷[1] 吴冉[1] 王若峥[1] 

机构地区：[1]新疆医科大学附属肿瘤医院放疗一科,乌鲁木齐830011

出　　处：《新疆医科大学学报》2013年第7期902-904,共3页Journal of Xinjiang Medical University

基　　金：乌鲁木齐市人才工程重点培养对象专项基金项目(P112310001);国家自然基金项目(81160327)

摘　　要：目的探讨新疆汉族人群HLA-DRB1位点基因多态性与鼻咽癌(nasopharyngeal carcinoma,NPC)遗传易感性的关系。方法应用聚合酶链反应/序列特异性引物(PCR-SSP)方法对50例鼻咽癌患者(NPC组)及43例正常体检者(对照组)进行HLA-DRB1位点基因分型,比较两组HLA-DRB1位点等位基因频率分布差异。结果 NPC组DRB1*1201较对照组降低(χ2=6.785,P=0.009,OR=0.319,CI=0.131～0.777),P值经Bonferroni校正后HLA-DRB1位点等位基因频率差异均无统计学意义(Pc>0.05)。结论新疆汉族人群HLA-DRB1位点基因多态性与鼻咽癌遗传易感性无相关性。Objective To investigate whether the polymorphisms of HLA-DRBI alleles were associated with nasopharyngeal carcinoma （NPC）. Methods q50 NPC patients（NPC group）and 43 normal controls （con-trol group） of local Han people in Xinjiang were genotyped for HLA-DRB1 by PCR/SSP technique. Results The frequencies of HLA class 11 gene DRB1 ＊ 1201 were lower in NPC group than those in controls, no significance differences were observed between the two groups in HLA-DRB1 loci after Bonferroni correc-tion （Pc 〉0.05）. Conclusion The results could not prove that there was significant correlation between NPC and HLA-DRB1 locus in Xinjiang han population.

关 键 词：鼻咽癌 HLA-DRB1 多态性 等位基因 

分 类 号：R730.3[医药卫生—肿瘤] R739.6[医药卫生—临床医学]