1341例羊水细胞染色体核型分析  

Chromosome karyotype analysis of 1341 amniotic fluid samples

作　　者：黄郁晶[1] 王岳平[1] 

机构地区：[1]中国医科大学附属盛京医院临床遗传科,辽宁沈阳110004

出　　处：《中国优生与遗传杂志》2013年第6期51-52,共2页Chinese Journal of Birth Health & Heredity

基　　金：国家自然基金资助(项目编号:81201274)

摘　　要：目的探讨羊水细胞培养染色体核型分析技术在细胞遗传学产前诊断中的应用及意义。方法 1341例妊娠17～28周的孕妇在超声引导下行羊膜腔穿刺术,进行细胞培养及染色体核型分析。结果 1341例标本一次培养成功1330例,培养成功率为99.2%。共检出异常核型90例,异常率为6.8%,其中21-三体24例,18-三体7例,其他异常核型59例。结论羊水细胞学检查作为一项产前诊断技术对于指导优生优育,降低缺陷儿的出生具有重要意义。Objective：To investigate the significance of chromosome karyotype analysis of amniotic fluid cells in prenatal diagnosis.Methods：Amniocentesis by guided B-ultrasound was performed on 1341 cases of pregnant women.Chromosome karyotypes from amniotic fluid samples were then analyzed.Results：1330 cells were cultured successfully,and the success rate of primary culture was 99.2%.90 abnormal karyotypes were detected,including 24 21-trisomes,7 18-trisomes.Conclusion：Chromosome karyotype analysis of amniotic fluid cells has great significance in prenatal diagnosis.

关 键 词：产前诊断 羊水细胞培养 染色体核型分析 

分 类 号：R714.5[医药卫生—妇产科学]