离子迁移谱及其在药学领域的应用  

Ion mobility spectrometry and its applications in pharmaceutical research and development

作　　者：冯雪[1] 尹利辉[1] 金少鸿[1] 张学博[1] 朱俐[1] 赵瑜[1] 张锐[1] 

机构地区：[1]中国食品药品检定研究院,北京100050

出　　处：《药物分析杂志》2013年第7期1109-1114,共6页Chinese Journal of Pharmaceutical Analysis

基　　金：国家科技支撑计划-保健食品中违禁物质检测技术研究(2011BAZ02015-2)

摘　　要：离子迁移谱(IMS)是基于大气压下在弱电场中进行气相离子分析的一种检测技术,具有灵敏度高、分析速度快、易于实现便携等特点,应用前景广泛,在药学领域可用于药品质量控制及药品生产过程中洁净度的验证等方面。本文将在介绍离子迁移谱基本原理及其仪器研究进展的基础上,进一步重点阐述离子迁移谱在药学领域的各种应用。Ion mobility spectrometry（IMS） is an analysis detection technology which an separate gas phase ions in the weak electric field at the atmospheric pressure,with high sensitivity,rapid analysis and portability.IMS has broad application prospects,which can be used for drug quality control and the cleanness validation of manufacturing equipment in the pharmaceutical industry.This review introduced the basic principle of IMS and its progress on the instruments,and further focused on its various applications in the pharmaceutical field.

关 键 词：离子迁移谱(IMS) 气相离子迁移分析 灵敏度 药学应用 

分 类 号：R917[医药卫生—药物分析学]