红茶延长秀丽线虫在环境氧化应激中寿命的研究  

Black Tea Extend the Lifespan of Caenorhabditis elegans Nematode under Oxidative Stress

作　　者：张健炜[1] 熊哲[1] 高燕[1] 彭雨轩[1] 龚雨顺[1] 刘仲华[1] 

机构地区：[1]国家植物功能成分利用工程技术研究中心,湖南农业大学茶学教育部重点实验室,湖南长沙410128

出　　处：《茶叶科学》2013年第4期295-300,共6页Journal of Tea Science

基　　金：国家自然科学基金(31270733);湖南省教育厅项目(12W005)

摘　　要：以秀丽隐杆线虫(Caenorhabditis elegans)为模型,研究了红茶在环境氧化应激中对秀丽线虫寿命的延长作用,并对相关蛋白与酶活力进行了测定。研究结果表明,在环境氧化应激条件下50 mg/L的红茶处理后的秀丽线虫存活时间显著延长;体内超氧化物歧化酶(SOD)活力升高40.8%,谷胱甘肽过氧化物酶(GSH-Px)活力升高340.8%;SKN-1::GFP蛋白表达上调了10%,DAF-16::GFP蛋白表达上调了18%。The effect of black tea extracts on extending the lifespan of Caenorhabditis elegans nematode under Oxidative stress was studied by the authors. Results showed the mean lifespan was significantly extended upon the concentration of 50 mg/L black tea extract treatment under oxidative stress. Further studies demonstrated that the significant up-regulation of stress-resistance-related enzyme including superoxide dismutase-3 （SOD-3） by 40.8% and GSH-Px by 340.8%, and its up-regulation of stress-resistance-related proteins, including SKN-1：：GFP by 10% and DAF-16：：GFP by 18%. These results indicate that black tea extracts can extend the lifespan of Caenorhabditis elegans nematode against oxidative stress.

关 键 词：红茶 秀丽线虫 氧化应激 

分 类 号：TS272.52[农业科学—茶叶生产加工]