广西汉族婴幼儿血管瘤与HLA-DQA1，-DQB1基因的相关性  

The Association between HLA-DQA1, -DQB1 Genes and Infantile Hemangioma in GuangXi Han Population

作　　者：郑凤丽[1] 陈深[2] 严煜林[2] 

机构地区：[1]广西医科大学第一附属医院皮肤性病科,广西南宁530021 [2]广西医科大学第六附属医院口腔科,广西玉林537000

出　　处：《中国皮肤性病学杂志》2013年第8期772-774,共3页The Chinese Journal of Dermatovenereology

基　　金：广西自然科学基金资助项目(2010GXNSFA013169)

摘　　要：目的探讨HLA基因连锁不平衡情况与婴幼儿血管瘤发病的相关性。方法 77例广西汉族婴幼儿血管瘤为实验组,并选择103例汉族健康正常儿童作为正常对照组,应用聚合酶链反应—序列特异性引物(PCR-SSP)法分析研究对象的HLA-DQA1,-DQB1基因位点的多态性。根据等位基因及单倍体情况分别进行两组间比较,分析血管瘤与HLA-DQA1,-DQB1等位基因及单倍体的相关性。结果与正常对照组相比,婴幼儿血管瘤组中HLA-DQA1*0102基因频率显著降低(P=0.003);单倍型HLA-DQA1*0401-DQB1*0301显著降低(P=0.008)。结论在广西地区的汉族人群中,HLA-DQA1*0102等位基因及单倍型HLA-DQA1*0401-DQB1*0301可能与该地区汉族婴幼儿血管瘤的遗传易感性相关联。Objective To discover the influence of linkage disequilibrium of HLA-DQA1,-DQB1 genes on infantile he- mangioma in Guangxi han population. Methods Polymerase chain reaction - sequence specific primer （ PCR - SSP） was used to assay the HLA-DQA1 ,-DQB1 allele and haploid in 77 infant patients with heman- gioma and 103 healthy controls in Guangxi Han population. Results The allele frequency of HLA-DQA1 ＊ 0102 and haploid frequency of DQA1 ＊ 0401-DQB1 ＊ 0301 were significantly less in infant patients with he- mangioma than those of the controls （P = O. 003,0.008）. Conclusion The results indicate that HLA-DQA1 ~ 0102 allele and -DQA1 ＊ 0401-DQB1 ＊ 0301 haploid may be correlated with the genetic susceptibility to infantile hemangioma in GuangXi Han population.

关 键 词：血管瘤 人类白细胞抗原 等位基因 单倍体 

分 类 号：R739.5[医药卫生—肿瘤]