新型脲嘧啶类化合物的合成及其除草活性  

Synthesis and Herbicidal Activity of Novel Uracil Derivatives

作　　者：李公春[1] 鞠志宇[1] 吴长增[1] 杨风岭[1] 

机构地区：[1]许昌学院化学化工学院,河南许昌461000

出　　处：《贵州农业科学》2013年第7期108-110,共3页Guizhou Agricultural Sciences

基　　金：河南省自然科学项目"环境友好型尿嘧啶类光合作用抑制剂的设计;合成及构效关系研究"(082300420110);河南省教育厅自然科学项目"新型尿嘧啶类除草剂的研究"(2007150036)

摘　　要：为了发掘具有良好除草活性的新型化合物,以6-三氟甲基-1-取代脲嘧啶为原料,在无水碳酸钾条件下,N,N-二甲基甲酰胺为溶剂,使用硫酸二甲酯进行甲基化,合成了4个3-甲基-6-三氟甲基-1-取代脲嘧啶类化合物。并采用油菜平皿法和稗草小杯法对所合成的化合物除草活性进行研究。结果表明:合成的目标化合物均通过1 H NMR确认;在浓度0.1g/L时,化合物b[3-甲基-1-(3,4-二氯苄基)-6-三氟甲基脲嘧啶]对稗草株高抑制率为67%,化合物a[3-甲基-1-(4-氟苄基)-6-三氟甲基脲嘧啶]对油菜根长抑制率为19%。In order to find new lead compounds with good herbicidal activities, taking 6- （Trifluoromethyl）-l-substituted uracil derivatives as raw material and N, N-dimethylformamide as the solvent under the condition of anhydrous potassium carbonate, four 3-methyl-6- （Trifluoromethyl）-l- substituted uracil derivatives were synthesized by using dimethyl sulfate. And their structures were confirmed by 1 H NMR and elementary analysis. The preliminary bioassay results indicated that compounds b exhibited herbicidal activities of 67% against Echinochloa crusgalli at 0. 1 g/L, and compounds a exhibited herbicidal activities of 19% against Brassica napus at 0.1 g/L.

关 键 词：三氟甲基 脲嘧啶 合成 除草活性 

分 类 号：O626.4[理学—有机化学] S482.4[理学—化学]