抑郁青少年认知行为治疗前后脑电超慢涨落图  

Change of Encephalofluctuograph of Adolescents with Depression through CBT

作　　者：刘学军[1] 周旭辉[1] 马静[1] 刘光亚[1] 叶海森[1] 肖慧琼[1] 

机构地区：[1]湖南省脑科医院精神科,长沙410007

出　　处：《中国健康心理学杂志》2013年第8期1124-1127,共4页China Journal of Health Psychology

基　　金：湖南省自然科学基金项目(11JJ3108)

摘　　要：目的探索认知心理治疗缓解青少年抑郁症状的生物学原理。方法对73例患轻中度抑郁症的青少年进行8周的认知行为心理治疗。根据治疗末的疗效,将62例完成治疗的患者分为有效组和抵抗组;比较两组之间治疗后2、4、8周末,以及两组治疗前后的自身脑电超慢涨落图改变。结果对于有效组的青少年,EFG检测的r-氨基丁酸相对功率在治疗第2、4、8周末均高于治疗前(t=-2.58,P<0.05;t=-3.92,-4.14;P<0.01);五羟色胺相对功率在治疗第4、8周末均高于治疗前(t=-3.17,-2.07;P<0.05);在治疗第4周末高于抵抗组(t=-2.13,P<0.05);去甲肾上腺素相对功率在治疗第4周末高于治疗前(t=-2.08,P<0.05);谷氨酸相对功率在治疗第2、4、8周末均高于治疗前(t=-2.12,P<0.05;t=-3.00,P<0.01;t=-2.81,P<0.05);乙酰胆碱相对功率在治疗第2周末均高于治疗前(t=2.34,P<0.05);多巴胺相对功率在治疗第2、4、8周末均高于治疗前(t=-2.26,P<0.05;t=-5.83,-7.36;P<0.01);第4、8周末均高于抵抗组(t=2.47,3.36;P<0.01)。而抵抗组的EFG检测的多巴胺相对功率在治疗第4、8周末均高于治疗前(t=-2.89,-3.08;P<0.01)。结论认知行为心理治疗能改变脑内神经递质的活动。Objective To explore the biological mechanism of CBT on relieving the depression of adolescents.Methods A total of 73 adolescents who met the DSM-IV criteria for depression disorder were involved.The subjects got CBT for 8 weeks.The efficacy was assessed with HAMD,and the power of neurotransmitters was valued with encephalofluctuograph at baseline and at the 2th,4th,8th weekends of the treatment.Results 62 subjects completed the study and 11 were dropped out.35 subjects were efficient to CBT,their power of GABA at the 2th,4th,8th weekends after the treatment were higher than that at the baseline（t=-2.58,P0.05;t=-3.92,-4.14;P0.01）;Their power of 5-HT at the 4th and 8th weekends after the treatment were higher than that at the baseline（t=-3.17,-2.07;P0.05）;At the 4th weekend after the treatment,it was higher than inefficient group＇s（t=-2.13,P0.05）;Their power of noradrenalin at the 4th weekend after the treatment was higher than that at the baseline（t=-2.08,P0.05）;Their power of glutamate at the 2th,4th and 8th weekends after the treatment was higher than that at the baseline（t=-2.12,P0.05;t=-3.00,P0.01;t=-2.81,P0.05）;Their power of acetylcholine at the 2th weekend after the treatment was higher than that at the baseline（t=2.34,P0.05）;Their power of dopamine at the 2th,4th and 8th weekends after the treatment were higher than that at the baseline（t=-2.26,P0.05;t=-5.83,-7.36;P0.01）;At the 4th and 8th weekend after the treatment,it was higher than inefficient group＇s（t=2.47,3.36;P0.01）;The inefficient group＇s power of dopamine at the 4th and 8th weekends after the treatment were higher than that at the baseline（t=-2.89,-3.08;P0.01）.Conclusion CBT can change the power of neurotransmitter of patients with depression.

关 键 词：抑郁症 青少年 认知行为心理治疗 脑电超慢涨落图 

分 类 号：R741.044[医药卫生—神经病学与精神病学]