抑郁症患者认知功能损害的特点  

Cognitive Impairment Characteristic of Patients with Depression.

作　　者：张顺[1] 王丽萍[1] 郑琳[1] 唐颖[1] 田悦[1] 李娜[1] 

机构地区：[1]开滦精神卫生中心,063001

出　　处：《中国健康心理学杂志》2013年第8期1142-1145,共4页China Journal of Health Psychology

摘　　要：目的探讨抑郁症患者认知功能损害的特点。方法连续选取开滦精神卫生中心40例住院抑郁症患者,年龄在18～50周岁之间,符合ICD-10抑郁发作诊断标准,汉密尔顿抑郁量表(HAMD-17)得分均大于20分,进行8周的抗抑郁治疗,分别于基线和治疗8周后评定HAMD-17,DAS,同时实施WCST和Stroop测验。另外随机选取30例进行健康体检的正常人为对照组进行评定。结果疗前抑郁症患者多项评定结果均较对照组差,包括DAS评分(t=6.95,P<0.01)、Stroop总时间(t=11.84,P<0.01)、Stroop错误数(t=10.85,P<0.01)、WCST总应答数(t=7.64,P<0.01)、WCST完成分类数(t=-5.39,P<0.01)、WCST错误应答数(t=5.21,P<0.01)、WCST完成第一个分类所需应答数(t=3.81,P<0.01)、WCST持续错误数(t=4.91,P<0.01)和WCST非持续错误数(t=4.01,P<0.01)。治疗后患者的DAS评分(t=3.81,P<0.01)、Stroop总时间(t=5.85,P<0.01)、Stroop错误数(t=6.78,P<0.01)、WCST总应答数(t=10.04,P<0.01)、WCST完成分类数(t=-3.18,P<0.01)、WCST错误应答数(t=3.01,P<0.01)、WCST完成第一个分类所需应答数(t=2.10,P<0.05)、WCST持续错误数(t=3.42,P<0.01)的成绩较治疗前有改善(P<0.01),但DAS评分(t=2.79,P<0.01)、Stroop总时间(t=2.22,P<0.05)、WCST完成分类数(t=-2.87,P<0.01)、WCST错误应答数(t=2.01,P<0.05)、WCST持续错误数(t=2.24,P<0.05)仍较对照组差。结论抑郁症患者除情感症状外,还存有明显的认知功能损害,并且在抑郁症状改善后仍存有认知损害。Objective To investigate cognitive impairment characteristic of patients with depression.Methods A total of 40 patients with depression were continuously selected for study group.All patients＇ HAMD-17 scores were greater than 20.HAMD-17 and DAS scale were used to measure every patient＇s condition at the beginning and after treatment 8 weeks.At the same time all patients were asked to complete WCST and Stroop test.30 health persons were selected randomly for control group.Results Before treatment,DAS score（t=6.95,P0.01）,Stroop total time（t=11.84,P0.01）,Stroop error number（t=10.85,P0.01）,WCST responses answer（t=7.64,P0.01）,WCST categories completed（t=-5.39,P0.01）,WCST errors responses（t=5.21,P0.01）,WCST trials to compete first category（t=3.81,P0.05）,WCST perseverative responses errors（t=4.91,P0.01） and WCST nonperseverative responses errors（t=4.01,P0.01）were worse in patients with depression than the control group（P0.01）.After treatment 8 weeks,DAS score（t=3.81,P0.01）,Stroop total time（t=5.85,P0.01）,Stroop error number（t=6.78,P0.01）,WCST responses answer（t=10.04,P0.01）,WCST categories completed（t=-3.18,P0.01）,WCST errors responses（t=3.01,P0.01）,WCST trials to compete first category（t=2.10,P0.05）and WCST perseverative responses errors（t=3.42,P0.01） were improved.And DAS score（t=2.79,P0.01）,Stroop total time（t=2.22,P0.05）,WCST categories completed（t=-2.87,P0.01）,WSCT errors responses（t=2.01,P0.01）,WCST perseverative responses errors（t=2.24,P0.05） were still worse than the control group（P0.01）.Conclusion In addition to the emotional symptoms,patients with depression have obvious cognitive impairment.The cognitive impairment of patients with depression will exist when depression symptom is improved.

关 键 词：精神病学 抑郁症患者 认知功能损害 情感症状 

分 类 号：R749.4[医药卫生—神经病学与精神病学]