Combined Application of 5% Natamycin and 0.2% Fluconazole for the Treatment of Fungal Keratitis  

作　　者：Hua Gong Xiangming Gong 

机构地区：[1]Liwan Hospital of Guangzhou Medical College [2]Zhongshan Ophthalmic Center, Sun Yat-sen University

出　　处：《Eye Science》2013年第2期84-87,共4页眼科学报（英文版）

摘　　要：Purpose: To observe the clinical efficacy of combined use of 5% natamycin and 0.2% fluconazole for the treatment of fungal keratitis. Methods:A total of 65 cases diagnosed with fungal keratitis by direct smear and/or fungus culture from January 2010 to January 2013 were enrolled in this study.The duration from the onset of symptoms to admission to our ophthalmic center ranged from 9 to 90 d (mean 29.5 ±19.1 d) in the severe group, which significantly differed from the 7 to 36 d (mean 16.6±7.1 d) in the non-severe group (P<0.01). All cases were divided into non-severe and severe groups based on the degree of corneal inflammation. All cases were treated with topical use of 5% natamycin and 0.2% fluconazole once per hour. The same clinical and examination protocols were adopted for both groups. Results:In the non-severe group,23 of the 24 patients (95.8%) were healed, and 1 (4.2%) showed treatment effica cy. In the severe group,12 of 41 patients (29.3%) were healed, 11(26.8%) showed clinical efficacy, and 18(43.9%) showed no efficacy. The patients between two groups significantly differed in terms of efficacy (P<0.01). Conclusion:Combined use of 5% natamycin and 0.2% fluconazole is efficacious in treating fungal keratitis, especially mild or moderate infections.Purpose： To observe the clinical efficacy of combined use of 5% natamycin and 0.2% fluconazole for the treatment of fun- gal keratitis. Methods： A total of 65 cases diagnosed with fungal keratitis by direct smear and/or fungus culture from January 2010 to January 2013 were enrolled in this study. The duration from the onset of symptoms to admission to our ophthalmic center ranged from 9 to 90 d （mean 29.5±19.1 d） in the severe group, which significantly differed from the 7 to 36 d （mean 16.6±7.1 d） in the non-severe group （P〈0.01）. All cases were divided into non-severe and severe groups based on the degree of corneal inflammation. All cases were treated with topical use of 5% natamycin and 0.2% fluconazole once per hour. The same clinical and examination protocols were adopted for both groups. Results： In the non-severe group, 23 of the 24 patients （95.8%） were healed, and 1 （4.2%） showed treatment effica cy. In the severe group, 12 of 41 patients （29.3%） were healed, 11 （26.8%） showed clinical efficacy, and 18（43.9%） showed no efficacy. The patients between two groups significantly dif- fered in terms of efficacy （P〈0.01）. Conclusion： Combined use of 5% natamycin and 0.2% flu- conazole is efficacious in treating fungal keratitis, especially mild or moderate infections.

关 键 词：纳他霉素 角膜炎 真菌性 氟康唑 治疗 临床疗效 应用 联合使用 

分 类 号：R772.21[医药卫生—眼科]