植物乳杆菌F1208对便秘大鼠胃肠道功能的影响  

Effect of Lactobacillus plantarum F1208 on Gastrointestinal Functions in Constipated Rats

作　　者：彭芝榕[1,2] 刘晓梅[1,2] 倪学勤[1,3] 杨杰[1] 邹昭勇[1] 邱春红[1] 曾东[1,3] 

机构地区：[1]四川农业大学动物医学院动物微生态研究中心,四川雅安625014 [2]四川农业大学动物医学院生物工程系,四川雅安625014 [3]动物疫病与人类健康四川省重点实验室,四川雅安625014

出　　处：《食品科学》2013年第13期243-246,共4页Food Science

基　　金：教育部留学回国人员科研启动基金资助项目(0835-1);四川农业大学本科生科研兴趣项目(2011037)

摘　　要：目的:研究植物乳杆菌F1208对便秘模型大鼠胃肠道功能的改善作用。方法:将雄性Wistar大鼠随机分为健康组、便秘组、番泻叶组和3个剂量植物乳杆菌给药组,用盐酸洛派叮胺制造便秘大鼠模型,造模后各实验组按2mL/(kg.d)的剂量灌喂相应实验药物。观察记录各组大鼠采食量、饮水量、体质量增加量、24h内粪便粒数,测定粪便含水量,粪便活菌计数和小肠炭末推进率。结果:植物乳杆菌F1208给药7d后可明显改善便秘大鼠采食量、饮水量,促进大鼠生长发育,增加排便粒数和粪便含水量,抑制肠道肠球菌、肠杆菌的生长繁殖,显著提高便秘大鼠小肠炭末推进率。结论:植物乳杆菌F1208具有改善便秘大鼠胃肠道功能的作用。Purpose： The objective of this study is to evaluate the regulatory effect of Lactobacillus plantarum F1208 on gastrointestinal functions in constipated rats.Methods： Male Wistar rats were randomly divided into health group,constipation group,senna group,and Lactobacillus plantarum high-,middle-and low-dosage groups.A rat model of loperamide hydrochloride-induced constipation was established.Each group was treated with corresponding drugs at 2 mL/（kg.d） for 7 days.During the experiment,feed intake,water intake,body quality increase,fecal number and water content,live bacterial count in feces and gastrointestinal transit ratio were monitored.Results： The administration with Lactobacillus plantarum F1208 for 7 days in constipated rats significantly improved the feed intake and water intake,promoted the growth and development of rats,increased the number and water content of feces within 24 hours,restrained the growth of intestinal bowel enterobacter and enterbacteriaceae,and improved gastrointestinal transit ratio.Conclusion： Lactobacillus plantarum F1208 has improved gastrointestinal functions in constipated rats.Conclusion： Lactobacillus plantarum F1208 has improvement gastrointestinal function in constipation rats.

关 键 词：植物乳杆菌 便秘 胃肠道功能 大鼠 

分 类 号：R37[医药卫生—病原生物学] TS201.3[医药卫生—基础医学]