中国汉族人群食管癌遗传易感基因多态性的研究进展  

Progress in research of polymorphisms of genes associated with susceptibility to esophageal cancer in Chinese Han population

作　　者：莫赛军[1] 柯少瑞[1] 张佳彤[1] 杨胜利[1] 

机构地区：[1]郑州大学基础医学院基础肿瘤学教研室,河南省郑州市450001

出　　处：《世界华人消化杂志》2013年第21期2045-2050,共6页World Chinese Journal of Digestology

基　　金：国家自然科学基金资助项目;No.81101686;河南省教育厅科学技术研究重点基金资助项目;No.12A310008~~

摘　　要：食管鳞癌(esophageal squamous cell carcinoma,ESCC)是我国常见的恶性肿瘤之一,其易感基因的遗传多态性是影响个体食管癌易感性的重要因素.中国汉族人群食管癌遗传易感基因主要包括代谢酶相关基因、DNA切除修复相关基因、相关的抑癌基因、癌基因和细胞因子基因等.本文主要对近年研究的中国汉族人群食管鳞癌易感相关的抑癌基因、癌基因及细胞因子等进行总结和分析.结果表明上述ESCC遗传易感基因的多态基因型在中国汉族人群中具有明显的地域分布,这为食管癌的区域诊断、监测及早期筛查提供了重要的理论基础.Esophageal squamous cell carcinoma （ESCC） is one of most common malignant tumors in Chi- na, and the polymorphisms of genes associated with susceptibility to ESCC are important fac- tors affecting individual tumor susceptibility. Genes associated with susceptibility to ESCC in Chinese Han population mainly contain me- tabolizing enzyme-associated genes, nucleotide excision repair genes, methylenetetrahydrofo- late reductase gene, tumor suppressor genes, oncogenes, and cytokines The genotypes of genes associated with susceptibility to ESCC have obvious regional distribution in ChineseHan population. This review aims to summa- rize and analyze the polymorphisms of genes associated with susceptibility to ESCC, includ- ing tumor suppressor genes and genes encod- ing oncogenes and cytokines, in Chinese Ha population.

关 键 词：食管鳞癌 遗传易感基因 多态性 地域分布 中国汉族人群 

分 类 号：R735.1[医药卫生—肿瘤]