Green tea catechins prevent obesity through modulation of peroxisome proliferator-activated receptors  

作　　者：YAN JingQi ZHAO Yan ZHAO BaoLu 

机构地区：[1]State Key Laboratory of Brain & Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences [2]Department of Food Sciences and Technology, Harbin Institute of Technology at Weihai

出　　处：《Science China(Life Sciences)》2013年第9期804-810,共7页中国科学（生命科学英文版）

基　　金：supported by the National Natural Science Foundation of China (30170239, 30930036)

摘　　要：Epidemiological evidence and experimental studies suggest that drinking green tea is associated with a lower risk of obesity and related diseases. However, the mechanisms of these effects are not clear. In the present study, we investigated the anti-obesity mechanisms of green tea catechins (GTCs) through modulation of peroxisome proliferator activated-receptor (PPAR) pathways in high-fat diet-induced obesity in rats. GTC supplementation significantly attenuated the increased body and liver weights and the elevated serum and liver triglyceride levels. Meanwhile, GTCs increased the PPARγ levels in subcutaneous white adipose tissue (SWAT) and decreased the PPAR levels in visceral white adipose tissue (VWAT). In addition, GTC treatment up-regulated the levels of PPARδ in SWAT, VWAT, and brown adipose tissue and increased the expression of genes involved in fatty acid oxidation in brown adipose tissue. Our results suggest that GTCs exert their anti-obesity mechanism in part by modulating PPAR signaling pathways.Epidemiological evidence and experimental studies suggest that drinking green tea is associated with a lower risk of obesity and related diseases. However, the mechanisms of these effects are not clear. In the present study, we investigated the anti-obesity mechanisms of green tea catechins （GTCs） through modulation of peroxisome proliferator activated-receptor （PPAR） pathways in high-fat diet-induced obesity in rats. GTC supplementation significantly attenuated the increased body and liver weights and the elevated serum and liver triglyceride levels. Meanwhile, GTCs increased the PPARγ levels in subcutaneous white adipose tissue （SWAT） and decreased the PPAR levels in visceral white adipose tissue （VWAT）. In addition, GTC treatment up-regulated the levels of PPARδ in SWAT, VWAT, and brown adipose tissue and increased the expression of genes involved in fatty acid oxidation in brown adipose tissue. Our results suggest that GTCs exert their anti-obesity mechanism in part by modulating PPAR signaling pathways.

关 键 词：OBESITY green tea catechins peroxisome proliferator activated-receptors （PPARs） HYPERLIPIDEMIA metabolic syndrome 

分 类 号：R285.5[医药卫生—中药学]