亚裔黄种人青少年黄斑厚度正常值研究与探讨  

Normal macular thickness in healthy Asian yellow race children

作　　者：陈思[1] 肖林[1] 任骁方[1] 金恩忠[1] 

机构地区：[1]北京大学第九临床医学院暨首都医科大学附属北京世纪坛医院眼科,100038

出　　处：《中华医学科研管理杂志》2013年第4期281-284,共4页Chinese Journal of Medical Science Research Management

基　　金：北京市首都医学发展科研基金（2011-2008-08）

摘　　要：目的探讨国人及亚裔黄种青少年黄斑厚度正常值，为该人群黄斑厚度异常相关疾病的诊断提供参考。方法检索万方、CNKI、Pubmed、Medline等中英文数据库，应用googlescholar搜索引擎对文献进行补充，对国人及亚裔黄种青少年人群黄斑厚度研究的相关文献进行筛选并采用自制表格进行数据提取，通过多个小样本均数、标准差的合并公式，求出各研究黄斑区的合并均数、合并标准差，采纳正常国人黄斑厚度值作为参考。结果文献筛选后最终对12篇文献进行数据合并。合并结果为黄斑中心凹最小厚度、黄斑中心凹（1mm直径区）平均厚度分别为143．89±17．32＂m（n一2062眼）、181．60±17．93“m（n一1974眼）。最终将以上两个区域及黄斑旁中心凹1～3mm直径区、3～6mm直径区各4个象限厚度的数据合并值与成年国人相应区域黄斑厚度值进行比较。按年龄分层进一步分析青少年黄斑厚度特点。结论正常国人及亚裔黄种人青少年黄斑不同区域厚度值与成人存在差别，儿童黄斑厚度随年龄的变化趋势与成人不同，因此临床诊断青少年黄斑厚度异常相关疾病时应综合考虑年龄、屈光度、眼轴、种族、性别等因素。此外，更合理的正常参考值范围尚待大样本横断面研究提出。Objective To study the normal maeular thickness in children provide reference for the diagnosis of macular thickness abnormity in teenagers. Methods Databases including Wanfang, Puhmed and some others were searched for studies on macular thickness in Asian children. Data of macular thickness were extracted and were merged into only one by formulae. Results 12 studies were enrolled. The mean foveal minimum and central macular thickness were 143.89~ 17, 32~m（n= 2062 eyes） and 181.60=t=17.93t^m（n= 1974 eyes）, respectively. The eight areas of inner circle （1~ 3mm diameter） and the outer circle （3~6mm diameter） macular thickness were also calculated. The central macular area seemed thicker in pre-school children than school children. Conclusion Chidren＇s macular thickness have different characteristic from adults＇, so it is important to take age, refraction, axial length, race and sex into account before making an abnormal macular thickness diagnosis. Meanwhile, a large sample of population-based cross-sectional study in children is necessary for a more effective standard.

关 键 词：黄斑厚度 青少年 屈光状态 光相干断层成像 

分 类 号：R774.5[医药卫生—眼科]