羊水过多与胎儿染色体病的相关性分析  

Clinical analysis of the correlation between fetal chromosomal disorders and Polyhydramnios

作　　者：熊怡[1] 唐海深[1] 江陵[1] 

机构地区：[1]中山市博爱医院产前诊断中心,广东中山528400

出　　处：《中国计划生育和妇产科》2013年第4期72-73,78,共3页Chinese Journal of Family Planning & Gynecotokology

摘　　要：目的分析羊水过多与胎儿染色体病的相关性,探讨其临床价值。方法回顾2009年1月至2012年1月期间中山市博爱医院产前诊断病例,将产前诊断指征为单纯羊水过多的138例孕妇作为观察组,羊水过多合并其他产前诊断指征的135例孕妇作为对照组,分析胎儿的染色体结果。结果观察组中5例胎儿为染色体多态性,无非整倍体;对照组中16例胎儿染色体异常,其中包括7例非整倍体,9例为染色体多态性。对照组胎儿非整倍体率显著高于观察组,差异有统计学意义(P<0.05)。结论单纯性羊水过多胎儿妊娠结局良好,羊水过多合并其他产前诊断指征尤其是合并超声异常时提示胎儿非整倍体风险增加,应及时行侵入性产前诊断。Objective To analyze the value and the correlation between fetal chromosomal disorders and Polyhydramnios, and investigate the clinical significance of Polyhydramnios. Methods The clinical data from recruited pregnant women who underwent prenatal diagnostics in Bo＇ ai Hospital was analyzed retrospectively between Jan 2009 to Jan 2012, including 138 fetus with Polyhydramnios, 135 control cases with Polyhydramnios and other abnormal indicants. The outcome and chromosomal abnormalities were assessed. Results Totally 5 cases with chromosomal abnormalities and without no fetal chromosome aneuploidy were found in the 138 cases consulted. In the 135 control cases, 7 cases were aneuploidy and 9 cases were chromosomal structural abnormalities. Conclusion fetuses with isolated Polyhydramnios seem to have less likely develop to adverse outcome. Polyhydramnios with other abnormal indicants may be the risks to fetal chromosome aneuploidy （trisome or monomer）. There for the invasive prenatal diagnosis should be performed.

关 键 词：羊水过多 染色体异常 产前诊断 

分 类 号：R714.2[医药卫生—妇产科学]