羟基喜树碱、醛氢叶酸加氟苷联合方案治疗大肠癌54例报告  

Clinical Efficacy of CF+FUDR Combined with HCPT in the Treatment of 54 Cases of Advanced Colorectal Cancer

作　　者：申淑景[1] 马保根[1] 李醒亚[2] 朱霞 

机构地区：[1]河南省肿瘤医院,河南郑州450003 [2]河南医科大学第一附属医院,河南郑州450052

出　　处：《河南肿瘤学杂志》2000年第4期266-267,共2页Henan Journal of Oncology

摘　　要：目的　观察HCPT +CF +FUDR方案对大肠癌的临床疗效。方法　 5 4例Dukes’D期大肠癌患者 ,CF每天 10 0mg ,第 1～ 5天静滴 :FUDR每天 30 0～ 40 0mg/m2 ,第 1～ 5天继CF后静滴 ;HCPT每天 6～ 8mg/m2 ,第 1～ 10天静滴。每 2 8天重复为 1周期 ,所有患者都接受 4～ 6个周期化疗。结果　CR 6例 (11 1% ) ,PR 2 3例 (42 6 % ) ,CR +PR 5 3 7% (2 9/5 4)。其主要毒副作用为骨髓抑制和消化道反应。结论　HCPT +CF +FUDR方案治疗晚期大肠癌有较好的疗效 ,不良反应能为绝大多数患者所耐受。Objective To observe the clinical effect of CF+FUDR combined with HCPT in the treatment of 54 patients with Dukes' D phase colorectal cancer.Method All the patients were treated with CF 100 mg administered intravenously followed by FUDR 300～400mg/m 2 daily through day 1～5, HCPT 6～8mg/m 2 daily through day 1～10. Treatment was recycled every 28 days and patients were treated for 4～6 cycles.Results Six of 54 patients got complete response and 23 patients got part response. Overall response rate was 53.7%. Adverse effects were moderate.Conclusion The regimen of HCPT+CF+FUDR is effective and safe in the treatment of advanced colorectal cancer.

关 键 词：羟基喜树碱 氟苷 醛氢叶酸 联合化疗 大肠癌 

分 类 号：R735.340.5[医药卫生—肿瘤]