微管解聚酶MCAK的研究进展和展望  

Progress in Microtubule Depolymerase MCAK

作　　者：张良余[1] 姚雪彪[1] 

机构地区：[1]中国科学技术大学安徽细胞动力学与化学生物学省级实验室,合肥230027

出　　处：《中国细胞生物学学报》2013年第8期1186-1195,共10页Chinese Journal of Cell Biology

摘　　要：微管骨架是决定细胞可塑性与动力学的重要亚细胞结构,其动态性的高度可控是细胞健康的重要保证。在细胞内,微管动力学主要由微管相关蛋白调控。微管结合蛋白MCAK(mitotic centromere-associated kinesin)是细胞内主要的微管解聚酶之一,它通过调节纺锤体微管的动态性,保证有丝分裂中染色体的忠实分离。MCAK在有丝分裂中的活性受到多种激酶的严格调控。MCAK活性的异常与多种肿瘤的发生发展密切相关。The cellular function of microtubule depends on its closely regulated dynamics. In cells, microtubule dynamics is modulated by microtubule-associated proteins. MCAK （mitotic centromere-associated kinesin）, a key mi- crotubule depolymerase, orchestrates faithful chromosome segregation in mitotic cells by regulating spindle microtubule dynamics. The microtubule depolymerase activity of MCAK is closely regulated by a variety of mitotic kinases. More and more data indicates that deregulation of MCAK is correlated with tumorigenesis.

关 键 词：微管 有丝分裂 微管解聚酶 MCAK 磷酸化 肿瘤 

分 类 号：R730.2[医药卫生—肿瘤]