抗抑郁药物治疗对老年血管性痴呆患者执行功能的影响  

The effect of antidepressant on executive function in old patients with vascular dementia

作　　者：郭雪冰[1] 莫煊[2] 张明琛[3] 

机构地区：[1]新疆医科大学校医院,乌鲁木齐830011 [2]新疆维吾尔自治区人民医院临床心理科,乌鲁木齐830000 [3]新疆医科大学第一附属医院内分泌科,乌鲁木齐830054

出　　处：《新疆医科大学学报》2013年第9期1323-1325,共3页Journal of Xinjiang Medical University

基　　金：新疆维吾尔自治区自然科学基金(2012211a067)

摘　　要：目的探讨抗抑郁药物治疗对老年血管性痴呆患者执行功能的影响。方法将60例诊断为血管性痴呆(VD)的患者随机分成治疗组与对照组,分别给予盐酸多奈哌齐及盐酸多奈哌齐+抗抑郁药物治疗4w。采用简易智能精神状态检查量表(MMSE)、执行性画钟作业(CLOX)及Stroop测验对两组治疗前后执行功能进行评定,对比两组治疗前后CLOX1、Stroop1、Stroop2评分。结果治疗组VD患者在服用盐酸多奈哌齐并加用SSRI类抗抑郁药物治疗4w后,执行功能获得改善,与治疗前比较,差异有统计学意义(P<0.05)。对照组VD患者在单独服用盐酸多奈哌齐4w后,执行功能有一定程度改善,但与治疗前比较差异无统计学意义(P>0.05)。而且治疗后,治疗组较对照组执行功能改善明显,差异具有统计学意义(P<0.05)。结论抗抑郁药物治疗可以改善老年VD患者的执行功能。Objective To discuss the effect of antidepressant on executive function in old patients with vas-cular dementia .Methods Sixty patients diagnosed VD were divided into twe groups in randomization , treatment and control group .Treatment group was given donepezil hydrochloride and antidepressants . The control group was given donepezil hydrochloride only .Both for 4 weeks .All patients were evaluated with MMSE ,CLOX and Stroop test to assess the level of the executive function before and after the thera-py .Results The executive function of the treatment group improved after therapy of donepezil hydrochlo-ride and antidepressants for 4 weeks （P〈0 .05） .The executive function of the control group also observed improved but not siginificant difference （P〉0 .05） .After the therapy ,the treatment group had better ex-ecutive function than the control group obviously （P 〈0 .05） .Conclusion Antidepressants can improve the executive function in old patients with vascular dementia .

关 键 词：血管性痴呆 执行功能 抗抑郁药物治疗 

分 类 号：R749[医药卫生—神经病学与精神病学]