高脂饮食对阿霉素肾病大鼠肾小球系膜基质的影响  

Effect of High-lipid Diet on Glomerular Mesangial Matrix in Adriamycin-induced Nephrotic Rats

作　　者：宋红梅[1] 李学旺[1] 魏珉[1] 朱传酉 

机构地区：[1]中国医学科学院中国协和医科大学协和医院儿科,北京100730

出　　处：《中国医学科学院学报》2000年第5期470-475,F003,共7页Acta Academiae Medicinae Sinicae

摘　　要：目的 探讨高脂饮食对阿霉素肾病大鼠肾小球硬化的影响。方法 应用病理、免疫组化及分子生物学方法结合图像分析技术，观察高脂饮食对大鼠血胆固醇、尿蛋白、肾脏病理形态学改变以及肾小球系膜基质产生的影响。结果 在非肾病组及肾病组，高脂饮食大鼠的血胆固醇较标准饮食大鼠明显升高，分别为（ 2.2± 0.3） g/L vs(0.9± 0.1)To determined the effect of hypercholesterolemia induced by high-lipid diet on glomerulosclerosis.Methods Urinary protein excretion and serum cholesterol were assayed ,Image analysis and techniques of pathology ,immunohistochemistry,molecular biology were used to determine morphological changes in glomeruli and the production of glomerular mesangial matrixes in adriamycin-induced nephrotic syndrome (NS)and non-NS rats fed with standard chow and high-lipid chow.Results The serum total cholesterol level was significantly higher in rats with high-lipid chow in both non-NS〔 (2 2± 0 3)g/L vs (0 9± 0 1)g/L,P

关 键 词：阿霉素性肾病 高脂饮食 肾小球系膜基质 

分 类 号：R692.02[医药卫生—泌尿科学]