生存蛋白与口腔疾病间的关系  

Relationship between survivin and oral diseases

作　　者：李倩[1] 潘亚萍[1,2] 

机构地区：[1]中国医科大学口腔医学院口腔生物学教研室 [2]中国医科大学附属口腔医院牙周科,沈阳110002

出　　处：《国际口腔医学杂志》2013年第5期674-677,共4页International Journal of Stomatology

基　　金：国家自然科学基金资助项目(81070834;81271153)

摘　　要：生存蛋白(survivin)具有调控细胞有丝分裂和抑制程序性细胞死亡的双重功能,可干扰细胞的增殖与程序性死亡,进而影响疾病的发生发展进程。近年来,生存蛋白与口腔疾病间的关系备受瞩目,本文就生存蛋白及其与口腔肿瘤、牙周病和唾液腺发育间的关系等研究进展作一综述。Survivin, a member of the inhibitor of apoptosis protein family, functions as a regulator of mitosis and cell-death decisions. Snrvivin affects the initiation and progression of diseases by interfering with cell proliferation and apoptosis. In recent years, the relationship between survivin and oral diseases has attracted considerable research attention. This article focuses on the biological functions of survivin as well as relevant research progress in oral cancer, periodontal diseases, and salivary gland development.

关 键 词：生存蛋白 有丝分裂 程序性细胞死亡 口腔肿瘤 牙周病 唾液腺发育 

分 类 号：R78[医药卫生—口腔医学]