492对反复自然流产夫妇的染色体核型分析  

Analysis on the chromosome karyotypes of 492 patients with the recurrent spontaneous abortion

作　　者：周琴[1] 张玢[1] 缪婷婷[1] 郑芳秀[1] 张晓青[1] 

机构地区：[1]南京医科大学附属常州妇幼保健院,江苏常州213000

出　　处：《中国优生与遗传杂志》2013年第9期37-38,51,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨外周血染色体数目和结构异常与死胎、畸形、反复自然流产的关系,为产前检查和预防流产提供科学根据。方法对常州市妇幼保健院门诊2010年7月至2012年10月就诊的492例反复自然流产夫妇外周血做淋巴细胞培养,进行染色体核型分析。结果 492例患者共检出异常核型78例。其中染色体平衡易位14例,占总数的2.85%;罗氏易位5例,占总数的1.02%;染色体倒位7例,占1.42%;染色质多肽性48例,占9.76%;另见染色体部分缺失1例;衍生1例;重复1例;标记1例。结论染色体核型异常是导致死胎、畸形、反复自然流产的重要原因之一,进行细胞学遗传学染色体检查,有助于这类夫妇的生育指导。Objective： To explore the relationships between the stillbirth tetus, teratism, recurrent spontaneous abortion and the abnormal number and constitution of chromosome in the patients＇ peripheral blood in order to provide scientific supports for antenatal care and prevent abortion. Methods ： By investigating 492 outpatients with recurrent spontaneous abortion in Changzhou Maternal and Child Healthy Care Hospital from July. 1, 2010 to Oct. 30, 2012, their peripheral Lymphocytes were cultured and the chromosome karyotypes were analyzed. Results ： There were 78 cases of abnormal karyotype in 492 patients with habitual abortion. In these, 14 cases were balanced translocation with the ratio of 2. 85%. 5 cases were robersonian translocation with the ratio of 1.02% ; 7 cases were pericentric with the ratio of 1.42% ; 48 cases were chromosome pelymorphism with the ratio of 9. 76%. In addition, 1 case were delete; 1 case, derive; 1 case, duplication; 1 case, mark. Conclusion： The abnormal karyotype is one of important reasons which causes the stillbirth tetus, teratism and recurrent spontaneous abortion. It is benefit to guide those couples＇ procreation to investigate chromosome by cytogenetics＇ mehtods.

关 键 词：自然流产 染色体异常 核型分析 

分 类 号：R714.21[医药卫生—妇产科学]