Structures and biogenetic analysis of lipofuscin bis-retinoids  

作　　者：Ya-lin WU Jie LI Ke YAO 

机构地区：[1]College of Pharmaceutical Sciences,Zhejiang University [2]Eye Center,the Second Affiliated Hospital,School of Medicine,Zhejiang University

出　　处：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2013年第9期763-773,共11页浙江大学学报（英文版）B辑（生物医学与生物技术）

基　　金：supported by the National Natural Science Foundation of China(Nos.21202146 and 81271018);the Fundamental Research Funds for the Central Universities,China;the Zhejiang Key Laboratory Fund of China(No.2011E10006)

摘　　要：Age-related macular degeneration (AMD) is still an incurable blinding eye disease because of complex pathogenic mechanisms and unusual diseased regions.With the use of chemical biology tools,great progress has been achieved in improving the understanding of AMD pathogenesis.The severity of AMD is,at least in part,linked to the non-degradable lipofuscin bis-retinoids in retinal pigment epithelial (RPE).This material is thought to result from the lifelong accumulation of lysosomal residual bodies containing the end products derived from the daily phagocytosis of rod outer segments by RPE cells.Here,we present previously recognized bis-retinoids with focus on structures and biosynthetic pathways.In addition to a brief discussion on the mutual conversion relationships of bis-retinoids,future perspectives and the medical relevance of such studies on these lipofuscin constituents are also highlighted.Age-related macular degeneration （AMD） is still an incurable blinding eye disease because of complex pathogenic mechanisms and unusual diseased regions.With the use of chemical biology tools,great progress has been achieved in improving the understanding of AMD pathogenesis.The severity of AMD is,at least in part,linked to the non-degradable lipofuscin bis-retinoids in retinal pigment epithelial （RPE）.This material is thought to result from the lifelong accumulation of lysosomal residual bodies containing the end products derived from the daily phagocytosis of rod outer segments by RPE cells.Here,we present previously recognized bis-retinoids with focus on structures and biosynthetic pathways.In addition to a brief discussion on the mutual conversion relationships of bis-retinoids,future perspectives and the medical relevance of such studies on these lipofuscin constituents are also highlighted.

关 键 词：Age-related MACULAR degeneration(AMD) LIPOFUSCIN Retinal pigment epithelial(RPE) Bis-retinoids STRUCTURES Biogenesis Conversion relationships 

分 类 号：R774.5[医药卫生—眼科]