LIPOFUSCIN

作品数:13被引量:23H指数:2
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相关领域:医药卫生更多>>
相关机构:闽江学院更多>>
相关期刊:《World Journal of Gastroenterology》《Annals of Eye Science》《International Journal of Ophthalmology(English edition)》《Chinese Medical Journal》更多>>
相关基金:国家自然科学基金福建省自然科学基金更多>>
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荧光淬灭剂TrueBlack Lipofuscin对珊瑚自体荧光的消除及其在免疫荧光标记中的应用
《应用海洋学学报》2023年第3期426-433,共8页赖庆娜 王路 陈建明 
福建省自然科学基金(2020J01855)。
自体荧光是生物体内部组织成分在吸收光时自然发出的荧光,会影响人工标记荧光的有效识别,严重干扰对抗体标记的目的蛋白荧光的观察及数据分析,在珊瑚冰冻切片免疫荧光标记研究中尤为突显。为更有效地去除珊瑚组织切片中的自体荧光,本研...
关键词:海洋生物学 珊瑚 自体荧光 免疫荧光标记 冰冻切片 荧光淬灭剂 
Vicious cycle of lipid peroxidation and iron accumulation in neurodegeneration被引量:7
《Neural Regeneration Research》2023年第6期1196-1202,共7页Instituto de Salud Carlos III Irene Villalón-García Suleva Povea-Cabello MónicaÁlvarez-Córdoba Marta Talaverón-Rey Juan MSuárez-Rivero Alejandra Suárez-Carrillo Manuel Munuera-Cabeza Diana Reche-López Paula Cilleros-Holgado Rocío Piñero-Pérez JoséA.Sánchez-Alcázar 
supported by FIS PI16/00786(2016)and FIS PI19/00377(2019)grants;the Ministerio de Sanidad,Spain and the Fondo Europeo de Desarrollo Regional(FEDER Unión Europea);Spanish Ministry of Education,Culture and Sport.This activity has been co-financed by the European Regional Development Fund(ERDF)and by the Regional Ministry of Economic Transformation,Industry,Knowledge and Universities of the Junta de Andalucía,within the framework of the ERDF Andalusia operational program 2014-2020 Thematic objective“01-Reinforcement of research,technological development and innovation”through the reference research project CTS-5725 and PY18-850(to JASA).
Lipid peroxidation and iron accumulation are closely associated with neurodegenerative diseases,such as Alzheimer’s,Parkinson’s,and Huntington’s diseases,or neurodegeneration with brain iron accumulation disorders....
关键词:4-hidroxynonenal ferroptosis IRON lipid peroxidation LIPOFUSCIN NEURODEGENERATION neurodegeneration with brain iron accumulation oxidative stress PLA2G6-associated neurodegeneration 
Characteristics of normal human retinal pigment epithelium cells with extremes of autofluorescence or intracellular granule count被引量:1
《Annals of Eye Science》2021年第1期11-19,共9页Katharina Bermond Andreas Berlin Ioana-Sandra Tarau Christina Wobbe Rainer Heintzmann Christine A.Curcio Kenneth R.Sloan Thomas Ach 
Dr.Werner Jackstädt Foundation(TA),NIH/NEI 1R01EY027948(TA,RH,CAC),1R01EY06109(CAC).
Background:Cells of the retinal pigment epithelium(RPE)accumulate different kinds of granules(lipofuscin,melanolipofuscin,melanosomes)within their cell bodies,with lipofuscin and melanolipofuscin being autofluorescent...
关键词:Retinal pigment epithelium(RPE) GRANULES autofluorescence(AF) LIPOFUSCIN melanolipofuscin MELANOSOMES 
Effects of Ingested Baccharis dracunculifolia D.C.(Asteraceae)Extract in the Liver of Prochilodus lineatus Fish
《Microscopy Research》2019年第3期27-38,共12页Jeffesson De Oliveira-Lima Bruno Fiorelini Pereira Joao Rodolfo Tuckumantel Valim Thiago Gazoni Dimitrius Leonardo Pitol Flavio Henrique Caetano 
the Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior(CAPES)support
Baccharis dracunculifolia, popularly known in Brazil as “alecrim-do-campo”, is widely recognized for its therapeutic potential. The extract of its leaves is used for liver problems, stomach disorders and others. The...
关键词:Asteraceae HEPATOTOXICITY LIPOFUSCIN MACROPHAGES Prochilodus lineatus 
Evaluation of fundus autofluorescence patterns in age-related macular degeneration
《International Journal of Ophthalmology(English edition)》2016年第12期1779-1784,共6页Pradeep Venkatesh Pradeep Sagar Rohan Chawla Varun Gogia Rajpal Vohra Yog Raj Sharma 
AIM: To study the various morphological patterns of fundus autofluorescence (FAF) images in patients with age-related macular degeneration (AMD) in Indian population.METHODS: Totally 179 eyes of 104 patients wit...
关键词:age-related macular degeneration fundus autofluorescence LIPOFUSCIN choroidal neovascularization 
Ameliorative Action of Mn-Salen Derivatives on CCl<sub>4</sub>-Induced Destructive Effects and Lipofuscin-Like Pigment Formation in Rats’ Liver and Brain: Post-Treatment of Young Rats with EUKs
《CellBio》2014年第3期96-110,共15页Sakineh Meftah Razieh Yazdanparast Mahsa Molaei 
Lipofuscin-like pigments (LFPs) are highly oxidized cross-linked aggregates of oxidized protein and lipids which are formed under oxidative state conditions by free radicals produced. The present study aimed to evalua...
关键词:LIPOFUSCIN Aging Antioxidant Mn-Salen Derivaties Oxidative Stress 
Effects of organic solvents on two retinal pigment epithelial lipofuscin fluorophores, A2E and all-trans-retinal dimer被引量:1
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2014年第7期661-669,共9页Qiu-xia JIN Xin-ran DONG Jing-meng CHEN Ke YAO Ya-lin WU 
Project supported by the National Natural Science Foundation of China(Nos.21202146 and 81271018);the Fundamental Research Funds for the Central Universities;the Zhejiang Scientific Research Foundation for the Returned Overseas Chinese Scholars(No.J20120556);the Zhejiang Key Laboratory Fund of China(No.2011E10006)
Gene and drug therapies are being developed to al eviate vision loss in patients with Stargardt’s disease and age-related macular degeneration (AMD). To evaluate the therapeutic effects of these treatments, organic...
关键词:N-retinylidene-N-retinyl-ethanolamine (A2E) All-trans-retinal dimer LIPOFUSCIN Organic solvents Retinal pigment epithelial 
Structures and biogenetic analysis of lipofuscin bis-retinoids被引量:1
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2013年第9期763-773,共11页Ya-lin WU Jie LI Ke YAO 
supported by the National Natural Science Foundation of China(Nos.21202146 and 81271018);the Fundamental Research Funds for the Central Universities,China;the Zhejiang Key Laboratory Fund of China(No.2011E10006)
Age-related macular degeneration (AMD) is still an incurable blinding eye disease because of complex pathogenic mechanisms and unusual diseased regions.With the use of chemical biology tools,great progress has been ac...
关键词:Age-related MACULAR degeneration(AMD) LIPOFUSCIN Retinal pigment epithelial(RPE) Bis-retinoids STRUCTURES Biogenesis Conversion relationships 
Protective Effects of Flavonoid Baicalein against Menadione-Induced Damage in SK-N-MC Cells
《CellBio》2013年第2期35-44,共10页Maryam Moslehi Razieh Yazdanparast 
Oxidative damage and redox metal homeostasis loss are two contributing factors in brain aging and widely distributed neurodegenerative diseases. Oxidative species in company with excessive amounts of intracellular fre...
关键词:AGING BAICALEIN LIPOFUSCIN MENADIONE NEURODEGENERATIVE Disease OXIDATIVE Stress 
Lipofuscin-and Melanin-related Fundus Autofluorescence in Patients with Submacular Idiopathic Choroidal Neovascularization被引量:2
《Eye Science》2012年第3期138-142,共5页Xijia Peng Wenfang Zhang 
supported by a grant from the Science and Technology Support Project of Gansu Province(No.090NKCA093)
Purpose:.To compare melanin-related near-infrared fundus autofluorescence (NIA; excitation 787 nm, emission> 800 nm) with lipofuscin-related fundus autofluorescence (FAF; excitation 488 nm, emission > 500 nm) in patie...
关键词:自体荧光 新生血管 黑色素 脉络膜 脂褐素 眼底 患者 黄斑 
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