弥漫型非霍奇金淋巴瘤染色体异常与临床预后相关性探讨  

Correlative Study of Chromosomal Abnormality in Non - Hodgkin's Lymphoma and its Prognosis

作　　者：汪惠园[1] 程华枫[2] 勇威本 丘镜滢[4] 初雪梅 汪渊 

机构地区：[1]安徽医科大学附属医院血液科,合肥市230022 [2]淮北杨庄矿职工医院内科 [3]北京大学临床肿瘤学院内科 [4]北京大学人民医院血研所

出　　处：《中国肿瘤临床》2000年第11期815-817,共3页Chinese Journal of Clinical Oncology

基　　金：安徽省教委自然科学研究基金!(JL-96-077)

摘　　要：目的：探讨弥漫型非霍奇金淋巴瘤（ＮＨＬ）染色体异常与临床预后间关系。方法：采用短期培养，Ｇ显带方法对４６例弥漫型ＮＨＬ的淋巴结活检标本进行染色体核型分析并与临床结果进行联系。结果：６ｑ２１－２５断裂，３＋分别与短的中位生存期和高度恶性ＮＨＬ相关。结论：弥漫型ＮＨＬ染色体异常与临床结果间有相关性。Objective: To study the relationship between chromosomal abnormality of non- Hodgkin's lymphoma (NHL) and its prognosis. Methods: Forty - six lymph node specimens of NHL were cultured in 24 hours and analysed by G banding method. The result was associated with the clinical prognosis of the patients. Results and Conclusion: The mainly chromosomal abnormalities: breaks at 14q - 32. 18q21 .6q21 - 25; structural abnormalities of chromosome 17; trisomy3 .5 . 18 found in study, The results showed that the break of 6q21 - 25 and + 3 were correlated with the shortened median survival period and highly malignant NHL respectively.

关 键 词：非霍奇金淋巴瘤 染色体异常 预后 NHL 

分 类 号：R733.1[医药卫生—肿瘤]