胎儿肾盂扩张与染色体异常的关系及临床预后  

Study on clinical prognosis and relationship between fetal pyelectasis and chromosomal abnormalities

作　　者：李娟[1] 高健[1] 李亚丽[1] 楚伟[1] 余小平[1] 王方娜[1] 冉战玲[1] 梅冰[1] 霍平[1] 

机构地区：[1]河北省人民医院,河北石家庄050051

出　　处：《中国妇幼保健》2013年第28期4709-4711,共3页Maternal and Child Health Care of China

基　　金：河北省科学技术研究与发展计划重大项目〔11276102D〕

摘　　要：目的:探讨肾盂扩张胎儿的产前诊断结果及预后。方法:对155例肾盂扩张胎儿行产前诊断核型分析,并定期超声复查胎儿发育情况,电话随访妊娠结局及胎儿出生后生长发育状况。结果:155例肾盂扩张胎儿中染色体核型异常8例,其中4例为孤立性肾盂扩张,另4例合并染色体异常软标记。成功随访142例,其中终止妊娠16例,活产126例;126例活产儿中2例出现生长发育异常死亡,其余124例生长发育未见明显异常,其中122例产前超声检查肾盂宽度已恢复正常或较前缩小。结论:染色体异常是导致胎儿肾盂扩张的原因之一,轻度肾盂扩张不伴有超声结构严重异常并排除染色体畸变时大多数胎儿预后良好。超声发现胎儿肾盂扩张时,应仔细扫查胎儿其他部位有无结构异常,并行产前诊断染色体核型分析。Objective： To study the results of prenatal diagnosis and clinical prognosis of fetal pyelectasis, and provide basis for clinical genetic counseling. Methods： The karyotype analysis of fetal prenatal diagnosis of 155 cases of pyelectasis were performed, fetal de- velopment were regularly examinated by ultrasound, and outcome of pregnancy and fetal postnatal condition were recorded by telephone fol- low - up. Results ： In 155 cases of pyelectasis fetal, there were 8 abnormal chromosome karyotype, including 4 cases of solitary pyelectasis, another 4 cases with abnormal chromosome soft markers. 142 cases were followed up successfully, including 16 cases of pregnancy terminated and 126 postnatal births lived; 2 death cases owing to developmental abnormality were observed in the postnatal 126 live births, and the re- maining 124 cases of postpartum growth had no obvious abnormalities, including 122 cases of prenatal ultrasound examination of pelvis width had returned to normal or decreased. Conclusion ： Chromosome abnormality is one of the causes of fetal pyeleetasis; mild fetal pyeleetasis is not accompanied by other serious structural anomalies and the exclusion of chromosome aberration when most of the fetal prognosis is good. When we find fetal pyelectasis, we should carefully scan other parts of fetus if has no structural abnormalities, and analyse the prenatal diagnosis of chromosome karyotype.

关 键 词：胎儿 肾盂扩张 产前诊断 超声检查 染色体 

分 类 号：R714.5[医药卫生—妇产科学]