黑牛肝菌多糖对小鼠酒精性肾损伤保护作用的研究  

Protective effect of polysaccharides from Boletus aereus on alcoholic kidney injury of mice

作　　者：赵云霞[1] 陶眀煊 程光宇[2] 郭永月[1] 邢佳[1] 彭婕[1] 

机构地区：[1]南京师范大学金陵女子学院,江苏南京210097 [2]南京师范大学生命科学学院,江苏南京210046

出　　处：《食品工业科技》2013年第20期368-371,共4页Science and Technology of Food Industry

摘　　要：目的:研究黑牛肝菌多糖(RPBA)对酒精所致急性肝损伤小鼠肾损伤的保护作用。方法:小鼠被随机分为空白对照组、模型组、药物组(联苯双酯组,150mg/kg bw)、RPBA各剂量组(100、200、400mg/kg bw),连续灌胃30d,空白对照组按等量生理盐水灌胃。第31d给予50%乙醇(12mL/kg)建立动物急性肝损伤模型。小鼠处死后取肾脏测定各项抗氧化指标。结果:与模型组相比,RPBA各剂量组均能降低肾脏MDA含量(p<0.01),提高肾脏SOD活性、CAT活性、GSH-Px活性及GSH含量(p<0.01)。结论:RPBA能明显提高肾脏中抗氧化酶活性,减少脂质过氧化,对小鼠酒精性肾损伤具有明显保护作用。Objective ：The protective effect of refined polysaccharide from Boletus aereus（RPBA） on acute alcoholic hepatic injury of kidney ）n mice was investigated. Methods-Mice were randomly divided into blank control group, alcoholic model groups, Bifendate （150mg/kgbw） groups and RPBA （ 100,200,400mg/kg bw） groups. All mice were administered for 30d prior to the administration with dose of 50% alcohol（12mL/kg bw） except blank control group. 12h after alcohol treament,all mice were dislocation death to assay activities of antioxidant capabilities in kidney. Results.Contents of MDA in kidney revealed an obvious decrease（p〈0.01 ） in the RPBA treament groups when compared to the model group,while the contents of GSH and the activities of SOD,CAT,GSH-Px in the kidney exhibited an obvious increase（p〈0.01）. Conclusion RPBA could protect kidney from injury induced by alcohol in mice.

关 键 词：黑牛肝菌多糖 酒精性肾损伤 保护作用 抗氧化 

分 类 号：TS201.4[轻工技术与工程—食品科学]