微生物群结构、人类健康和癌症化学预防(英文)  

Microbiota Structures, Human Health and Cancer Chemoprevention

作　　者：牛韬 胡明 

机构地区：[1]Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston

出　　处：《化学进展》2013年第9期1601-1612,共12页Progress in Chemistry

摘　　要：在人类肠道中寄生着数以万亿计的微生物,它们的功能类似于一个多细胞器官。无论其巨大的数目和复杂性如何,这个微生物群通常以特定类型聚集出现。肠道菌群参与调节宿主的能量分解、多个代谢通路、信号转导、免疫系统平衡等,在宿主的生理活动中起着关键作用。微生物群与宿主共生,依附其上,适应寄宿环境并互相影响。肠道菌群组成的改变与多种复杂疾病例如炎性肠病、代谢性疾病和癌症相关。因此,针对微生物群的早期诊断和干预,特别是在癌症化学预防中,或许将在近期成为可能。The human gut harbors trillions of microbes that function as a multi-cell organ. This microbial community appears to cluster in certain types regardless of its vast number and complexity. The gut microbiota plays a key role in the host physiology since it is involed in energy breakdown, multiple host metabolic pathways, signaling, immune system balance etc. The microbiota codevelop with the host and is subject to pertubation and resilience. Changes in the composition of the gut microbiota have been associated with diverse, complex diseases including inflammatory bowel disease, metabolic disease and cancer. Therefore, microbiota-targeted early diagnosis and therapy may become possible in the near future, especially in the chemoprevention of cancer.

关 键 词：微生物群落 微生物组 诊断 治疗 化学预防 益生菌 益生元 

分 类 号：R730.1[医药卫生—肿瘤] R37[医药卫生—临床医学]