水解乳清蛋白对重症胰腺炎大鼠炎症反应的影响  

The immunomodulating effect of hydrolyzed whey protein on severe acute pancreatitis in rats

作　　者：沈峰[1] 夏志高[1] 王博文[1] 

机构地区：[1]广州市第一人民医院营养科,广东广州510180

出　　处：《中国农村卫生》2013年第04Z期212-213,共2页

摘　　要：目的研究水解乳清蛋白对重症胰腺炎大鼠炎症反应的影响。方法90只雄性大鼠随机分为对照组、实验组和空白组，每组各30只。将对照组及实验组大鼠制作成为重症胰腺炎模型，空白组作假手术处理，检测不同时段的血清淀粉酶。在肠内营养基础上，实验组添加水解乳清蛋白，对照组和空白组添加等量的普通蛋白粉，喂养一周后处死，测定胸腺指数、脾脏指数、IL-1、IL-6、TNF-α等。结果三组间的胸腺指数、脾脏指数、血清总蛋白及白蛋白均无显著性差别（P〉0．05）；对照组的IL-1、IL-6和TNF-α均显著性地高于实验组P〈0．05）。结论水解乳清蛋白可以减轻重症胰腺炎大鼠的炎症反应。Objective To investigate the immunomodulating effect of hydrolyzed whey protein on severe acute pancreatitis in rats. Methods 90 malc rats were randomly divided into control group, experimental group and sham--operation group and SAP model was constructed. The experimental group was fed with hydrolyzed whey protein while the controlgroup and sham--group were fed with ordinary protein and the levels of amylase were detected at different interval. A week later, thymus index, spleen index, total protein, albumin, IL-1, IL-6 and TNF-αwere detected. Results The thymus, spleen index, total protein and albumin among groups were not significantly different （P〉0.05）. However, the level of IL-1, IL-6 and TNF-α in experimental group were significantly lower than that of the control group （P〈0.05）. Conclusion The hydrolyzed whey protein may relieve the inflammatory response of SAP in rats.

关 键 词：水解乳清蛋白 重症胰腺炎 大鼠 炎症反应 

分 类 号：R576[医药卫生—消化系统] R459.3[医药卫生—内科学]