沙棘籽油抗抑郁作用  

Antidepressant Effect of Seabuckthorn Seed Oil

作　　者：田俊生[1] 郑晓芬[1] 张丽增[1] 秦雪梅[1] 

机构地区：[1]山西大学中医药现代研究中心,山西太原030006

出　　处：《食品科学》2013年第19期279-282,共4页Food Science

基　　金：国家自然科学基金项目(81102833;81173366);山西省基础研究项目(2012021031-2)

摘　　要：采用悬尾实验(TST)和强迫游泳实验(FST)观察沙棘籽油对小鼠不动时间的影响;采用慢性温和不可预知应激程序(CUMS)复制大鼠抑郁模型,观察沙棘籽油对大鼠体质量、糖水偏爱、行为活动等指标的影响,从而探讨沙棘籽油的抗抑郁作用,发现其新的功效。结果表明:沙棘籽油能明显减少小鼠悬尾实验和强迫游泳实验中的不动时间(P<0.05,P<0.01),对CUMS模型大鼠体质量、糖水偏爱、行为活动等指标均有不同程度的改善(P<0.05,P<0.01),表明沙棘籽油具有明显的抗抑郁作用。The effect of seabuckthorn seed oil on the immobility time in mice was investigated by tail suspension test （TST） and forced swimming test （FST）. Body weight, sucrose preference and open-field activities were conducted on mice with depression induced by chronic unpredictable mild stress （CUMS） to explore the antidepressant effect of seabuckthorn seed oil. The results showed that administration of seabuckthorn seed oil was capable of reducing the immobility time in FST and TST while other indices such as body weight, sucrose preference, open-field activities were increased significantly （P 〈 0.05, 0.01）. These findings implicated that seabuckthorn seed oil might be a potential antidepressant for developing functional foods or drugs.

关 键 词：沙棘籽油 抗抑郁 悬尾实验 强迫游泳实验 慢性温和不可预知应激 

分 类 号：TS201.2[轻工技术与工程—食品科学]