柠檬酸在产油酵母油脂积累过程中的中心作用  

The Central Role of Citrate in Lipid Accumulation in Oleaginous Yeasts

作　　者：唐文佳[1] 张怀渊[1] 陈卫[1,2] 宋元达[1] 

机构地区：[1]江南大学食品学院,江苏无锡214122 [2]江南大学食品科学与技术国家重点实验室,江苏无锡214122

出　　处：《食品科学》2013年第19期326-329,共4页Food Science

基　　金：国家自然科学基金面上项目(31171636;81071685)

摘　　要：产油酵母可以积累大量油脂,具有重要的应用价值,近年来,关于柠檬酸和脂质合成的关系的研究报道很多,研究发现产油酵母整个油脂积累的过程都需要柠檬酸的参与,油脂积累所需要的乙酰辅酶A主要由柠檬酸提供,柠檬酸在线粒体膜和细胞膜上的转运对产油酵母油脂含量的影响较大。细胞质和线粒体内的柠檬酸对油脂积累过程中的许多重要酶具有调节作用。柠檬酸是连接糖代谢与脂代谢的桥梁,在产油酵母油脂积累过程中起到中心作用。本文通过对柠檬酸在产油酵母油脂积累代谢的中心作用进行综述,以期为探究产油酵母油脂积累机制提供一定的参考。Oleaginous yeasts are capable of accumulating large amount of lipids and show great potential for industrial applications, which attracted the increasing research interests. In recent years, more researches have been carried out to investigate the relationship between citrate metabolism and lipid biosynthesis. It is now believed that that citrate participates in the metabolic process of lipid accumulation and provides acetyl-CoA for fatty acid biosynthesis in oleaginous yeasts. The transporting behavior of citrate from mitochondria and cytoplasm affects the lipid content in oleaginous yeasts. Citrates in cytoplasm and mitochondrial function as modulators of several key enzymes related to the metabolic process of lipid accumulation in oleaginous yeasts. Citrate acts as a bridge between glycolysis and lipid biosynthesis, and plays a central role in regulating lipid accumulation in oleaginous yeasts. In summary, the central role of citrate metabolism in lipid accumulation was reviewed, which will provide useful references for exploring the mechanism of lipid accumulation in oleaginous yeasts.

关 键 词：产油酵母 油脂积累 柠檬酸 柠檬酸转运蛋白 

分 类 号：Q939.97[生物学—微生物学]