牛磺酸对糖尿病大鼠血糖和血小板聚集的影响  

EFFECTS OF TAURINE ON BLOOD GLUCOSE AND PLATELET AGGREGATION IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

作　　者：葛慧[1] 陶亮[2] 于雯 揭秉章 梅节[1] 李惠玲[1] 

机构地区：[1]中山医科大学卫生学院营养系,广州510089 [2]中山医科大学药理教研室

出　　处：《营养学报》2000年第4期308-311,共4页Acta Nutrimenta Sinica

基　　金：中山医科大学卫生学院基金

摘　　要：目的　观察牛磺酸 (taurine,Tau)对糖尿病大鼠血糖、血小板计数、血小板聚集功能以及血小板中氧自由基代谢的影响。方法　在以链佐霉素诱导的糖尿病大鼠模型上 ,测定血糖以及二磷酸腺苷 (ADP)、凝血酶 (Thr)诱导的血小板最大聚集率、血小板计数、血小板中超氧化歧化酶 (SOD)的活性、丙二醛 (MDA)的含量。结果　糖尿病大鼠的血糖、以 ADP、Thr诱导的血小板最大聚集率明显高于正常组 ;血小板中 SOD活性及血小板计数下降、MDA含量升高。Tau治疗后糖尿病大鼠的血糖显著降低 ;血小板计数、血小板中 SOD的活性、MDA的含量及 ADP、Thr诱导的血小板最大聚集率无显著改变。结论　糖尿病大鼠血小板聚集功能增强可能与血小板中氧自由基代谢异常有关。Tau能降低糖尿病大鼠的血糖 ,但对其血小板功能和血小板中氧自由基的代谢无明显的影响。Objective: To investigate the effects of taurine on blood glucose, number of platelets in plasma, pletelet aggregation and metabolism of oxygen free radicals in diabetic rats. Methods: Diabetes was induced by a single injection (ip) of streptozotocin (STZ,70 mg/kg body weight). The rats were maintained on drinking water with or without taurine (1.5 g/kg body weight per day). The concentration of blood glucose, maximal aggregation rate of platelets induced by adenosine 5 diphosphate(ADP) or thrombin(Thr) and the number of platelets in plasma were measured. Metabolism of oxygen free radicals in platelets was assessed as superoxide dismutase(SOD) activity and content of malondialdehyde(MDA) in platelets. [WT5FZ]Results: [WT5BZ]The concentration of blood glucose and maximal aggregation rate of platelets induced by ADP or Thr were significantly higher in diabetic rats than in non diabetic rats. The diabetic rats showed decreased platelet number and SOD activity with higher MDA level. In taurine treated diabetic rats concentration of blood glucose was obviously decreased, but no significant change was found in platelet number, SOD activity, MDA content and aggregation of platelets induced by ADP or Thr. [WT5FZ] Conclusion: [WT5BZ]There is a correlation between the increase in platelet aggregability and the abnormal metabolism of oxygen free radicals in platelets and taurine can decrease the blood glucose level but has no significant effect on platelet aggregability and metabolism of oxygen free radicals in diabetic rats.

关 键 词：糖尿病 牛磺酸 血糖 氧自由基 

分 类 号：R587.1[医药卫生—内分泌]